Abstract

A secondary analysis of 1999-2002 Nebraska case-control data was conducted to assess the risk of non-Hodgkin lymphoma (NHL) associated with exposure to nitrate- and atrazine-contaminated drinking water. Water chemistry data were collected and weighted by well contribution and proximity of residence to water supply, followed by logistic regression to determine odds ratios (OR) and 95% confidence intervals (CI). We found no association between NHL risk and exposure to drinking water containing atrazine or nitrate alone. Risk associated with the interaction of nitrate and atrazine in drinking water was elevated (OR, 2.5; CI, 1.0-6.2). Risk of indolent B-cell lymphoma was higher than risk of aggressive B-cell lymphoma (indolent: OR, 3.5; CI, 1.0-11.6 vs. aggressive: OR, 1.9; CI, 0.6-5.58). This increased risk may be due to in vivo formation and subsequent metabolism of N-nitrosoatrazine. A larger study is warranted to confirm our findings.

Original languageEnglish (US)
JournalEnvironmental Health Insights
Volume7
DOIs
StatePublished - Jan 1 2013

Fingerprint

Atrazine
Water Supply
Herbicides
atrazine
Water supply
Potable water
Drinking Water
Nitrates
Non-Hodgkin's Lymphoma
nitrate
confidence interval
Odds Ratio
Confidence Intervals
drinking water
B-Cell Lymphoma
Cells
Metabolism
water chemistry
drinking water supply
public

Keywords

  • NHL
  • atrazine
  • drinking water
  • nitrate
  • nitrosamines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis
  • Management, Monitoring, Policy and Law
  • Pollution

Cite this

Atrazine and Nitrate in Public Drinking Water Supplies and Non-Hodgkin Lymphoma in Nebraska, USA. / Rhoades, Martha G.; Meza, Jane L.; Beseler, Cheryl L.; Shea, Patrick J.; Kahle, Andy; Vose, Julie M.; Eskridge, Kent M.; Spalding, Roy F.

In: Environmental Health Insights, Vol. 7, 01.01.2013.

Research output: Contribution to journalArticle

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