Atherogenic and anti-atherogenic factors in the human diet.

P. B. Addis, T. P. Carr, C. A. Hassel, Z. Z. Huang, G. J. Warner

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

New atherosclerosis causative factors and preventive modalities have been identified. Atherogenic factors include lipid oxidation products, such as cholesterol oxidation products, malonaldehyde and other aldehydes; trans-fatty acids; some saturated fatty acids (lauric, myristic and possibly palmitic acids); and myristic acid plus cholesterol. Lipid oxidation products are well suited to induce arterial damage, based on their known cytotoxic effects; evidence also indicates the possibility of plaque promotion and stimulation of thrombogenesis. Anti-atherogenic factors include antioxidants, fish oils and other polyunsaturates (if protected from oxidation), fibre and trace minerals such as copper, manganese, selenium and zinc. Iron is unique, being considered as both a potential promoter of atherosclerosis (component of ferritin, conceivably inducing lipid oxidation) and a possible anti-atherogenic component (of antioxidant enzyme catalase). It is apparent that an entire new series of research challenges has been uncovered.

Original languageEnglish (US)
Pages (from-to)259-271
Number of pages13
JournalBiochemical Society symposium
Volume61
DOIs
StatePublished - 1995

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Nutrition
Diet
Lipids
Oxidation
Atherosclerosis
Antioxidants
Cholesterol
Palmitic Acids
Trans Fatty Acids
Fish Oils
Myristic Acid
Trace Elements
Ferritins
Manganese
Selenium
Malondialdehyde
Aldehydes
Catalase
Zinc
Copper

ASJC Scopus subject areas

  • Biochemistry

Cite this

Atherogenic and anti-atherogenic factors in the human diet. / Addis, P. B.; Carr, T. P.; Hassel, C. A.; Huang, Z. Z.; Warner, G. J.

In: Biochemical Society symposium, Vol. 61, 1995, p. 259-271.

Research output: Contribution to journalReview article

Addis, P. B. ; Carr, T. P. ; Hassel, C. A. ; Huang, Z. Z. ; Warner, G. J. / Atherogenic and anti-atherogenic factors in the human diet. In: Biochemical Society symposium. 1995 ; Vol. 61. pp. 259-271.
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