Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine a after liver transplant

Cory A. Roberts, David L. Stern, Stanley J Radio

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background. Cardiotoxicity has been described in a group of pediatric patients receiving FK506 as a part of immunosuppression for orthotopic liver transplantation (OLT). Information regarding the cardiac pathology related to this agent is limited. Methods. Among the first 975 liver transplants at our institution (1985-1995), autopsy hearts were available for 19 patients (14 adults and 5 children) who received FK506 for a minimum of 1 week prior to death. Patients with excessive alcohol use, significant coronary artery disease, valvular disease, diabetes mellitus, or pretransplant hypertension were excluded from analysis. We compared heart weight (HW), heart weight-to-body weight ratio (HW/BW), ventricular septal (VS) thickness with left ventricular (LV) thickness ratio (VS/LV), and cardiac histologic findings of 12 OLT patients (7 adults, 5 children) who received FK506 with a group of 75 OLT patients (48 adults, 27 children) who received Cyclosporine (CsA) and 20 (10 adults, 10 children) age-comparable control patients without OLT. Results. All FK506 and CsA children and adults had cardiomegaly by HW, HW/BW (PFK506 peds<0.024, PCsA peds<0.028, PFK506 adults<0.017, PCsA adults<0.006) and increased VS/LV ratio 1.25FK506 (P<0.006) and 1.23CsA (P<0.006)(pediatric) and 1.09FK506 (P<0.0122) and 1.21CsA (P<0.0009) (adults), compared with control. Conclusion. Cardiomegaly by HW, HW/BW, and his. tology was uniformly present in both FK506 and CsA adult and pediatric OLT patients at autopsy. A relatively greater VS hypertrophy than LV was present in both transplant groups. We found no gross or histologic cardiac finding that separated these FK506 from CsA OLT patients at autopsy.

Original languageEnglish (US)
Pages (from-to)817-821
Number of pages5
JournalTransplantation
Volume74
Issue number6
DOIs
StatePublished - Sep 27 2002

Fingerprint

Cardiomegaly
Tacrolimus
Cyclosporine
Autopsy
Liver Transplantation
Transplants
Liver
Weights and Measures
Pediatrics
Left Ventricular Hypertrophy
Immunosuppression
Coronary Artery Disease
Diabetes Mellitus
Body Weight
Alcohols
Pathology
Hypertension

ASJC Scopus subject areas

  • Transplantation

Cite this

Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine a after liver transplant. / Roberts, Cory A.; Stern, David L.; Radio, Stanley J.

In: Transplantation, Vol. 74, No. 6, 27.09.2002, p. 817-821.

Research output: Contribution to journalArticle

@article{bba7873dedf24e16972de34781038216,
title = "Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine a after liver transplant",
abstract = "Background. Cardiotoxicity has been described in a group of pediatric patients receiving FK506 as a part of immunosuppression for orthotopic liver transplantation (OLT). Information regarding the cardiac pathology related to this agent is limited. Methods. Among the first 975 liver transplants at our institution (1985-1995), autopsy hearts were available for 19 patients (14 adults and 5 children) who received FK506 for a minimum of 1 week prior to death. Patients with excessive alcohol use, significant coronary artery disease, valvular disease, diabetes mellitus, or pretransplant hypertension were excluded from analysis. We compared heart weight (HW), heart weight-to-body weight ratio (HW/BW), ventricular septal (VS) thickness with left ventricular (LV) thickness ratio (VS/LV), and cardiac histologic findings of 12 OLT patients (7 adults, 5 children) who received FK506 with a group of 75 OLT patients (48 adults, 27 children) who received Cyclosporine (CsA) and 20 (10 adults, 10 children) age-comparable control patients without OLT. Results. All FK506 and CsA children and adults had cardiomegaly by HW, HW/BW (PFK506 peds<0.024, PCsA peds<0.028, PFK506 adults<0.017, PCsA adults<0.006) and increased VS/LV ratio 1.25FK506 (P<0.006) and 1.23CsA (P<0.006)(pediatric) and 1.09FK506 (P<0.0122) and 1.21CsA (P<0.0009) (adults), compared with control. Conclusion. Cardiomegaly by HW, HW/BW, and his. tology was uniformly present in both FK506 and CsA adult and pediatric OLT patients at autopsy. A relatively greater VS hypertrophy than LV was present in both transplant groups. We found no gross or histologic cardiac finding that separated these FK506 from CsA OLT patients at autopsy.",
author = "Roberts, {Cory A.} and Stern, {David L.} and Radio, {Stanley J}",
year = "2002",
month = "9",
day = "27",
doi = "10.1097/00007890-200209270-00015",
language = "English (US)",
volume = "74",
pages = "817--821",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Asymmetric cardiac hypertrophy at autopsy in patients who received FK506 (tacrolimus) or cyclosporine a after liver transplant

AU - Roberts, Cory A.

AU - Stern, David L.

AU - Radio, Stanley J

PY - 2002/9/27

Y1 - 2002/9/27

N2 - Background. Cardiotoxicity has been described in a group of pediatric patients receiving FK506 as a part of immunosuppression for orthotopic liver transplantation (OLT). Information regarding the cardiac pathology related to this agent is limited. Methods. Among the first 975 liver transplants at our institution (1985-1995), autopsy hearts were available for 19 patients (14 adults and 5 children) who received FK506 for a minimum of 1 week prior to death. Patients with excessive alcohol use, significant coronary artery disease, valvular disease, diabetes mellitus, or pretransplant hypertension were excluded from analysis. We compared heart weight (HW), heart weight-to-body weight ratio (HW/BW), ventricular septal (VS) thickness with left ventricular (LV) thickness ratio (VS/LV), and cardiac histologic findings of 12 OLT patients (7 adults, 5 children) who received FK506 with a group of 75 OLT patients (48 adults, 27 children) who received Cyclosporine (CsA) and 20 (10 adults, 10 children) age-comparable control patients without OLT. Results. All FK506 and CsA children and adults had cardiomegaly by HW, HW/BW (PFK506 peds<0.024, PCsA peds<0.028, PFK506 adults<0.017, PCsA adults<0.006) and increased VS/LV ratio 1.25FK506 (P<0.006) and 1.23CsA (P<0.006)(pediatric) and 1.09FK506 (P<0.0122) and 1.21CsA (P<0.0009) (adults), compared with control. Conclusion. Cardiomegaly by HW, HW/BW, and his. tology was uniformly present in both FK506 and CsA adult and pediatric OLT patients at autopsy. A relatively greater VS hypertrophy than LV was present in both transplant groups. We found no gross or histologic cardiac finding that separated these FK506 from CsA OLT patients at autopsy.

AB - Background. Cardiotoxicity has been described in a group of pediatric patients receiving FK506 as a part of immunosuppression for orthotopic liver transplantation (OLT). Information regarding the cardiac pathology related to this agent is limited. Methods. Among the first 975 liver transplants at our institution (1985-1995), autopsy hearts were available for 19 patients (14 adults and 5 children) who received FK506 for a minimum of 1 week prior to death. Patients with excessive alcohol use, significant coronary artery disease, valvular disease, diabetes mellitus, or pretransplant hypertension were excluded from analysis. We compared heart weight (HW), heart weight-to-body weight ratio (HW/BW), ventricular septal (VS) thickness with left ventricular (LV) thickness ratio (VS/LV), and cardiac histologic findings of 12 OLT patients (7 adults, 5 children) who received FK506 with a group of 75 OLT patients (48 adults, 27 children) who received Cyclosporine (CsA) and 20 (10 adults, 10 children) age-comparable control patients without OLT. Results. All FK506 and CsA children and adults had cardiomegaly by HW, HW/BW (PFK506 peds<0.024, PCsA peds<0.028, PFK506 adults<0.017, PCsA adults<0.006) and increased VS/LV ratio 1.25FK506 (P<0.006) and 1.23CsA (P<0.006)(pediatric) and 1.09FK506 (P<0.0122) and 1.21CsA (P<0.0009) (adults), compared with control. Conclusion. Cardiomegaly by HW, HW/BW, and his. tology was uniformly present in both FK506 and CsA adult and pediatric OLT patients at autopsy. A relatively greater VS hypertrophy than LV was present in both transplant groups. We found no gross or histologic cardiac finding that separated these FK506 from CsA OLT patients at autopsy.

UR - http://www.scopus.com/inward/record.url?scp=0037183895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037183895&partnerID=8YFLogxK

U2 - 10.1097/00007890-200209270-00015

DO - 10.1097/00007890-200209270-00015

M3 - Article

C2 - 12364862

AN - SCOPUS:0037183895

VL - 74

SP - 817

EP - 821

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 6

ER -