Asthma and Allergy

Lanny J. Rosenwasser, Jillian A. Poole

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter provides an overview of allergic diseases, specifically asthma. Allergic diseases are traditionally referred to as immediate or type I hypersensitivity reactions with allergen-specific IgE as an important factor. However, it is also apparent that critical cellular elements such as T lymphocytes constitute a major pathogenesis factor in the development of allergic diseases and, in particular, asthma. Dendritic cells and molecules such as the T cell receptor, major histocompatibility complex molecules, and co-stimulatory molecules are all necessary for inducing an allergic T cell inflammatory response. Clinical laboratory tools in conjunction with a thorough history and physical examination are used to diagnose properly and manage patients with allergic disorders. At present there is no in vitro test that confirms the presence of clinically relevant allergic disease. Quantitative specific IgE antibody immunoassays and Immunological assay advancements in determining cross-reactivity versus co-sensitization are explained. A comparison between skin testing and allergen specific-IgE immunoassays is presented.

Original languageEnglish (US)
Title of host publicationMeasuring Immunity
Subtitle of host publicationBasic Biology and Clinical Assessment
PublisherElsevier Ltd
Pages639-645
Number of pages7
ISBN (Print)9780124559004
DOIs
StatePublished - Dec 1 2005

Fingerprint

Allergies
Hypersensitivity
Asthma
Immunoglobulin E
T-cells
Immunoassay
Allergens
Molecules
Clinical laboratories
T-Lymphocytes
Immediate Hypersensitivity
T-Cell Antigen Receptor
Major Histocompatibility Complex
Dendritic Cells
Physical Examination
Assays
Skin
History
Antibodies
Testing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rosenwasser, L. J., & Poole, J. A. (2005). Asthma and Allergy. In Measuring Immunity: Basic Biology and Clinical Assessment (pp. 639-645). Elsevier Ltd. https://doi.org/10.1016/B978-012455900-4/50318-4

Asthma and Allergy. / Rosenwasser, Lanny J.; Poole, Jillian A.

Measuring Immunity: Basic Biology and Clinical Assessment. Elsevier Ltd, 2005. p. 639-645.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rosenwasser, LJ & Poole, JA 2005, Asthma and Allergy. in Measuring Immunity: Basic Biology and Clinical Assessment. Elsevier Ltd, pp. 639-645. https://doi.org/10.1016/B978-012455900-4/50318-4
Rosenwasser LJ, Poole JA. Asthma and Allergy. In Measuring Immunity: Basic Biology and Clinical Assessment. Elsevier Ltd. 2005. p. 639-645 https://doi.org/10.1016/B978-012455900-4/50318-4
Rosenwasser, Lanny J. ; Poole, Jillian A. / Asthma and Allergy. Measuring Immunity: Basic Biology and Clinical Assessment. Elsevier Ltd, 2005. pp. 639-645
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