Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms

Scott F Stoltenberg, Melissa K. Lehmann, Christa C. Christ, Samantha L. Hersrud, Gareth E. Davies

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Some of the genetic vulnerability for addiction may be mediated by impulsivity. This study investigated relationships among impulsivity, substance use problems and six neurexin-3 (NRXN3) polymorphisms. Neurexins (NRXNs) are presynaptic transmembrane proteins that play a role in the development and function of synapses. Methods: Impulsivity was assessed with the Barratt Impulsiveness Scale Version 11 (BIS-11), the Boredom Proneness Scale (BPS) and the TIME paradigm; alcohol problems with the Michigan Alcoholism Screening Test (MAST); drug problems with the Drug Abuse Screening Test (DAST-20); and regular tobacco use with a single question. Participants (n= 439 Caucasians, 64.7% female) donated buccal cells for genotyping. Six NRXN3 polymorphisms were genotyped: rs983795, rs11624704, rs917906, rs1004212, rs10146997 and rs8019381. A dual luciferase assay was conducted to determine whether allelic variation at rs917906 regulated gene expression. Results: In general, impulsivity was significantly higher in those who regularly used tobacco and/or had alcohol or drug problems. In men, there were modest associations between rs11624704 and attentional impulsivity (p= 0.005) and between rs1004212 and alcohol problems (p= 0.009). In women, there were weak associations between rs10146997 and TIME estimation (p= 0.03); and between rs1004212 and drug problems (p= 0.03). The dual luciferase assay indicated that C and T alleles of rs917906 did not differentially regulate gene expression in vitro. Conclusions: Associations between impulsivity, substance use problems and polymorphisms in NRXN3 may be gender specific. Impulsivity is associated with substance use problems and may provide a useful intermediate phenotype for addiction.

Original languageEnglish (US)
JournalDrug and Alcohol Dependence
Volume119
Issue number3
DOIs
StatePublished - Dec 15 2011

Fingerprint

Impulsive Behavior
Polymorphism
Tobacco
Alcohols
Luciferases
Gene expression
Pharmaceutical Preparations
Assays
Screening
Substance Abuse Detection
Boredom
Gene Expression
Cheek
Tobacco Use
Synapses
Alcoholism
Alleles
Proteins
Phenotype

Keywords

  • Cell adhesion protein
  • Impulsiveness
  • NRXN3
  • Substance use disorder

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms. / Stoltenberg, Scott F; Lehmann, Melissa K.; Christ, Christa C.; Hersrud, Samantha L.; Davies, Gareth E.

In: Drug and Alcohol Dependence, Vol. 119, No. 3, 15.12.2011.

Research output: Contribution to journalArticle

Stoltenberg, Scott F ; Lehmann, Melissa K. ; Christ, Christa C. ; Hersrud, Samantha L. ; Davies, Gareth E. / Associations among types of impulsivity, substance use problems and Neurexin-3 polymorphisms. In: Drug and Alcohol Dependence. 2011 ; Vol. 119, No. 3.
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abstract = "Background: Some of the genetic vulnerability for addiction may be mediated by impulsivity. This study investigated relationships among impulsivity, substance use problems and six neurexin-3 (NRXN3) polymorphisms. Neurexins (NRXNs) are presynaptic transmembrane proteins that play a role in the development and function of synapses. Methods: Impulsivity was assessed with the Barratt Impulsiveness Scale Version 11 (BIS-11), the Boredom Proneness Scale (BPS) and the TIME paradigm; alcohol problems with the Michigan Alcoholism Screening Test (MAST); drug problems with the Drug Abuse Screening Test (DAST-20); and regular tobacco use with a single question. Participants (n= 439 Caucasians, 64.7{\%} female) donated buccal cells for genotyping. Six NRXN3 polymorphisms were genotyped: rs983795, rs11624704, rs917906, rs1004212, rs10146997 and rs8019381. A dual luciferase assay was conducted to determine whether allelic variation at rs917906 regulated gene expression. Results: In general, impulsivity was significantly higher in those who regularly used tobacco and/or had alcohol or drug problems. In men, there were modest associations between rs11624704 and attentional impulsivity (p= 0.005) and between rs1004212 and alcohol problems (p= 0.009). In women, there were weak associations between rs10146997 and TIME estimation (p= 0.03); and between rs1004212 and drug problems (p= 0.03). The dual luciferase assay indicated that C and T alleles of rs917906 did not differentially regulate gene expression in vitro. Conclusions: Associations between impulsivity, substance use problems and polymorphisms in NRXN3 may be gender specific. Impulsivity is associated with substance use problems and may provide a useful intermediate phenotype for addiction.",
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AU - Davies, Gareth E.

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AB - Background: Some of the genetic vulnerability for addiction may be mediated by impulsivity. This study investigated relationships among impulsivity, substance use problems and six neurexin-3 (NRXN3) polymorphisms. Neurexins (NRXNs) are presynaptic transmembrane proteins that play a role in the development and function of synapses. Methods: Impulsivity was assessed with the Barratt Impulsiveness Scale Version 11 (BIS-11), the Boredom Proneness Scale (BPS) and the TIME paradigm; alcohol problems with the Michigan Alcoholism Screening Test (MAST); drug problems with the Drug Abuse Screening Test (DAST-20); and regular tobacco use with a single question. Participants (n= 439 Caucasians, 64.7% female) donated buccal cells for genotyping. Six NRXN3 polymorphisms were genotyped: rs983795, rs11624704, rs917906, rs1004212, rs10146997 and rs8019381. A dual luciferase assay was conducted to determine whether allelic variation at rs917906 regulated gene expression. Results: In general, impulsivity was significantly higher in those who regularly used tobacco and/or had alcohol or drug problems. In men, there were modest associations between rs11624704 and attentional impulsivity (p= 0.005) and between rs1004212 and alcohol problems (p= 0.009). In women, there were weak associations between rs10146997 and TIME estimation (p= 0.03); and between rs1004212 and drug problems (p= 0.03). The dual luciferase assay indicated that C and T alleles of rs917906 did not differentially regulate gene expression in vitro. Conclusions: Associations between impulsivity, substance use problems and polymorphisms in NRXN3 may be gender specific. Impulsivity is associated with substance use problems and may provide a useful intermediate phenotype for addiction.

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