Association of vascular risk factors with carotid intima media thickness after kidney transplant

Jennifer Lynn Larsen, Gerald C. Groggel, Jillian M. Witte, Terica L. Hudson, Elizabeth R. Lyden, Fang Yu, Urmila Mukherjee, Brian R. Stevens

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Vascular risk remains the greatest cause of mortality after kidney transplant (KTX). Carotid intima media thickness (CIMT) has not been studied after KTX. We have analyzed a cross section of KTX recipients to determine which risk factors best correlate with CIMT, representing vascular risk. Methods. All recipients 6 or more months after KTX with estimated glomerular filtration rate (GFR) ≥30 mL/min were invited to participate. Biomarkers of vascular risk were compared with CIMT. Results. A total of 342 recipients (192 men/150 women) with mean age of 52.3±0.6 years (±standard error of the mean) were studied 5.9±0.3 years since KTX (range: 0.5-33.7 years). Diabetes (P<0.01), smoking (P=0.01), and donor status (deceased vs. living) (P=0.04) were associated with CIMT. Age (P<0.0001), body mass index (BMI, P=0.0026), systolic blood pressure (P=0.0013), and pulse pressure (P<0.0001) were positively and diastolic pressure was negatively correlated with CIMT (P=0.0002) and pulse pressure (P=0.007). In multivariate analysis, race/ethnicity, GFR, as well as age, BMI, diabetes status, systolic and diastolic blood pressures, and pulse pressure were all independently associated with CIMT (P<0.05). There was no correlation between CIMT and lipids, homocysteine, high-sensitive C-reactive protein, 25-hydroxyvitamin D, or parathyroid hormone (PTH). Conclusions. In the largest study of CIMT after KTX, diastolic blood pressure was negatively correlated with vascular risk, whereas age, diabetes, BMI, systolic blood pressure, race/ethnicity, and GFR independently correlated with CIMT after KTX confirming the value of CIMT as a noninvasive means to assess vascular risk and factors unique to this patient population.

Original languageEnglish (US)
Pages (from-to)980-985
Number of pages6
JournalTransplantation
Volume90
Issue number9
DOIs
StatePublished - Nov 15 2010

Fingerprint

Carotid Intima-Media Thickness
Blood Pressure
Transplants
Kidney
Blood Vessels
Glomerular Filtration Rate
vascular factor
Homocysteine
Parathyroid Hormone
C-Reactive Protein
Body Mass Index
Multivariate Analysis
Biomarkers
Smoking

Keywords

  • Carotid intima media thickness
  • Diabetes
  • Kidney transplant
  • Vascular disease

ASJC Scopus subject areas

  • Transplantation

Cite this

Association of vascular risk factors with carotid intima media thickness after kidney transplant. / Larsen, Jennifer Lynn; Groggel, Gerald C.; Witte, Jillian M.; Hudson, Terica L.; Lyden, Elizabeth R.; Yu, Fang; Mukherjee, Urmila; Stevens, Brian R.

In: Transplantation, Vol. 90, No. 9, 15.11.2010, p. 980-985.

Research output: Contribution to journalArticle

Larsen, JL, Groggel, GC, Witte, JM, Hudson, TL, Lyden, ER, Yu, F, Mukherjee, U & Stevens, BR 2010, 'Association of vascular risk factors with carotid intima media thickness after kidney transplant', Transplantation, vol. 90, no. 9, pp. 980-985. https://doi.org/10.1097/TP.0b013e3181f62fe4
Larsen, Jennifer Lynn ; Groggel, Gerald C. ; Witte, Jillian M. ; Hudson, Terica L. ; Lyden, Elizabeth R. ; Yu, Fang ; Mukherjee, Urmila ; Stevens, Brian R. / Association of vascular risk factors with carotid intima media thickness after kidney transplant. In: Transplantation. 2010 ; Vol. 90, No. 9. pp. 980-985.
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abstract = "Background. Vascular risk remains the greatest cause of mortality after kidney transplant (KTX). Carotid intima media thickness (CIMT) has not been studied after KTX. We have analyzed a cross section of KTX recipients to determine which risk factors best correlate with CIMT, representing vascular risk. Methods. All recipients 6 or more months after KTX with estimated glomerular filtration rate (GFR) ≥30 mL/min were invited to participate. Biomarkers of vascular risk were compared with CIMT. Results. A total of 342 recipients (192 men/150 women) with mean age of 52.3±0.6 years (±standard error of the mean) were studied 5.9±0.3 years since KTX (range: 0.5-33.7 years). Diabetes (P<0.01), smoking (P=0.01), and donor status (deceased vs. living) (P=0.04) were associated with CIMT. Age (P<0.0001), body mass index (BMI, P=0.0026), systolic blood pressure (P=0.0013), and pulse pressure (P<0.0001) were positively and diastolic pressure was negatively correlated with CIMT (P=0.0002) and pulse pressure (P=0.007). In multivariate analysis, race/ethnicity, GFR, as well as age, BMI, diabetes status, systolic and diastolic blood pressures, and pulse pressure were all independently associated with CIMT (P<0.05). There was no correlation between CIMT and lipids, homocysteine, high-sensitive C-reactive protein, 25-hydroxyvitamin D, or parathyroid hormone (PTH). Conclusions. In the largest study of CIMT after KTX, diastolic blood pressure was negatively correlated with vascular risk, whereas age, diabetes, BMI, systolic blood pressure, race/ethnicity, and GFR independently correlated with CIMT after KTX confirming the value of CIMT as a noninvasive means to assess vascular risk and factors unique to this patient population.",
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AU - Larsen, Jennifer Lynn

AU - Groggel, Gerald C.

AU - Witte, Jillian M.

AU - Hudson, Terica L.

AU - Lyden, Elizabeth R.

AU - Yu, Fang

AU - Mukherjee, Urmila

AU - Stevens, Brian R.

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N2 - Background. Vascular risk remains the greatest cause of mortality after kidney transplant (KTX). Carotid intima media thickness (CIMT) has not been studied after KTX. We have analyzed a cross section of KTX recipients to determine which risk factors best correlate with CIMT, representing vascular risk. Methods. All recipients 6 or more months after KTX with estimated glomerular filtration rate (GFR) ≥30 mL/min were invited to participate. Biomarkers of vascular risk were compared with CIMT. Results. A total of 342 recipients (192 men/150 women) with mean age of 52.3±0.6 years (±standard error of the mean) were studied 5.9±0.3 years since KTX (range: 0.5-33.7 years). Diabetes (P<0.01), smoking (P=0.01), and donor status (deceased vs. living) (P=0.04) were associated with CIMT. Age (P<0.0001), body mass index (BMI, P=0.0026), systolic blood pressure (P=0.0013), and pulse pressure (P<0.0001) were positively and diastolic pressure was negatively correlated with CIMT (P=0.0002) and pulse pressure (P=0.007). In multivariate analysis, race/ethnicity, GFR, as well as age, BMI, diabetes status, systolic and diastolic blood pressures, and pulse pressure were all independently associated with CIMT (P<0.05). There was no correlation between CIMT and lipids, homocysteine, high-sensitive C-reactive protein, 25-hydroxyvitamin D, or parathyroid hormone (PTH). Conclusions. In the largest study of CIMT after KTX, diastolic blood pressure was negatively correlated with vascular risk, whereas age, diabetes, BMI, systolic blood pressure, race/ethnicity, and GFR independently correlated with CIMT after KTX confirming the value of CIMT as a noninvasive means to assess vascular risk and factors unique to this patient population.

AB - Background. Vascular risk remains the greatest cause of mortality after kidney transplant (KTX). Carotid intima media thickness (CIMT) has not been studied after KTX. We have analyzed a cross section of KTX recipients to determine which risk factors best correlate with CIMT, representing vascular risk. Methods. All recipients 6 or more months after KTX with estimated glomerular filtration rate (GFR) ≥30 mL/min were invited to participate. Biomarkers of vascular risk were compared with CIMT. Results. A total of 342 recipients (192 men/150 women) with mean age of 52.3±0.6 years (±standard error of the mean) were studied 5.9±0.3 years since KTX (range: 0.5-33.7 years). Diabetes (P<0.01), smoking (P=0.01), and donor status (deceased vs. living) (P=0.04) were associated with CIMT. Age (P<0.0001), body mass index (BMI, P=0.0026), systolic blood pressure (P=0.0013), and pulse pressure (P<0.0001) were positively and diastolic pressure was negatively correlated with CIMT (P=0.0002) and pulse pressure (P=0.007). In multivariate analysis, race/ethnicity, GFR, as well as age, BMI, diabetes status, systolic and diastolic blood pressures, and pulse pressure were all independently associated with CIMT (P<0.05). There was no correlation between CIMT and lipids, homocysteine, high-sensitive C-reactive protein, 25-hydroxyvitamin D, or parathyroid hormone (PTH). Conclusions. In the largest study of CIMT after KTX, diastolic blood pressure was negatively correlated with vascular risk, whereas age, diabetes, BMI, systolic blood pressure, race/ethnicity, and GFR independently correlated with CIMT after KTX confirming the value of CIMT as a noninvasive means to assess vascular risk and factors unique to this patient population.

KW - Carotid intima media thickness

KW - Diabetes

KW - Kidney transplant

KW - Vascular disease

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