Association of reduced zinc status with angiographically severe coronary atherosclerosis: A pilot study

George D. Giannoglou, Dimitris M. Konstantinou, Leda Kovatsi, Yiannis S. Chatzizisis, Dimitri P. Mikhailidis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalAngiology
Volume61
Issue number5
DOIs
StatePublished - Jul 1 2010

Fingerprint

Zinc
Coronary Artery Disease
Urine
Serum
Glycemic Index
Glucose
Myocardial Revascularization
Glycosylated Hemoglobin A
Coronary Angiography
Chest Pain
Fasting
Atherosclerosis
Diabetes Mellitus
Homeostasis
Myocardial Infarction
Insulin

Keywords

  • coronary artery disease
  • diabetes mellitus
  • impaired glucose homeostasis
  • zinc

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of reduced zinc status with angiographically severe coronary atherosclerosis : A pilot study. / Giannoglou, George D.; Konstantinou, Dimitris M.; Kovatsi, Leda; Chatzizisis, Yiannis S.; Mikhailidis, Dimitri P.

In: Angiology, Vol. 61, No. 5, 01.07.2010, p. 449-455.

Research output: Contribution to journalArticle

Giannoglou, George D. ; Konstantinou, Dimitris M. ; Kovatsi, Leda ; Chatzizisis, Yiannis S. ; Mikhailidis, Dimitri P. / Association of reduced zinc status with angiographically severe coronary atherosclerosis : A pilot study. In: Angiology. 2010 ; Vol. 61, No. 5. pp. 449-455.
@article{909df84bac5243a588943e922d494931,
title = "Association of reduced zinc status with angiographically severe coronary atherosclerosis: A pilot study",
abstract = "In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.",
keywords = "coronary artery disease, diabetes mellitus, impaired glucose homeostasis, zinc",
author = "Giannoglou, {George D.} and Konstantinou, {Dimitris M.} and Leda Kovatsi and Chatzizisis, {Yiannis S.} and Mikhailidis, {Dimitri P.}",
year = "2010",
month = "7",
day = "1",
doi = "10.1177/0003319710366702",
language = "English (US)",
volume = "61",
pages = "449--455",
journal = "Angiology",
issn = "0003-3197",
publisher = "SAGE Publications Inc.",
number = "5",

}

TY - JOUR

T1 - Association of reduced zinc status with angiographically severe coronary atherosclerosis

T2 - A pilot study

AU - Giannoglou, George D.

AU - Konstantinou, Dimitris M.

AU - Kovatsi, Leda

AU - Chatzizisis, Yiannis S.

AU - Mikhailidis, Dimitri P.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.

AB - In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.

KW - coronary artery disease

KW - diabetes mellitus

KW - impaired glucose homeostasis

KW - zinc

UR - http://www.scopus.com/inward/record.url?scp=77954037876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954037876&partnerID=8YFLogxK

U2 - 10.1177/0003319710366702

DO - 10.1177/0003319710366702

M3 - Article

C2 - 20529979

AN - SCOPUS:77954037876

VL - 61

SP - 449

EP - 455

JO - Angiology

JF - Angiology

SN - 0003-3197

IS - 5

ER -