Association of neonatal serum immunoglobulin G1 concentration with health and performance in beef calves

Reneé D. Dewell, Laura L. Hungerford, James Keen, William W. Laegreid, D. Dee Griffin, Gary P. Rupp, Dale M. Grotelueschen

Research output: Contribution to journalArticle

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Abstract

Objective - To evaluate associations between neonatal serum IgG1 concentration and pre- and postweaning morbidity and mortality rates and average daily gains (ADGs) in beef calves and define a cutoff point for serum IgG1 concentration necessary for optimal health and performance of beef calves. Design - Nonconcurrent cohort study. Animals - 1,568 crossbred beef calves. Procedure - Single radial immunodiffusion was used to quantitate IgG1 concentration in sera collected from calves between 24 and 72 hours after birth. Logistic regression, ANCOVA, and likelihood ratios were used to analyze data. Results - In the preweaning period, lower perinatal IgG1 concentrations were significantly associated with higher morbidity rates, higher mortality rates, and lower ADGs. Calves with serum IgG1 concentration < 2,400 mg/dL were 1.6 times as likely to become ill before weaning and 2.7 times as likely to die before weaning as calves with higher serum IgG1 concentrations. Calves with serum IgG1 concentration of at least 2,700 mg/dL weighed an estimated 3.35 kg (7.38 lb) more at 205 days of age than calves with lower serum IgG1 concentration. No significant association of serum IgG1 concentration with feedlot morbidity, death, or ADG was identified. Conclusions and Clinical Relevance - By use of likelihood ratios, the threshold of serum IgG1 concentration for optimal health and performance of calves was higher than values reported previously. Implementation and maintenance of management and intervention strategies designed for early detection and treatment of calves at risk for failure of passive transfer will likely result in increases in preweaning health and performance parameters.

Original languageEnglish (US)
Pages (from-to)914-921
Number of pages8
JournalJournal of the American Veterinary Medical Association
Volume228
Issue number6
DOIs
StatePublished - Mar 15 2006

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immunoglobulins
Immunoglobulins
beef
Immunoglobulin G
calves
Health
Serum
average daily gain
morbidity
Weaning
Morbidity
weaning
Red Meat
Mortality
Immunodiffusion
cohort studies
feedlots
crossbreds
Cohort Studies
Logistic Models

ASJC Scopus subject areas

  • veterinary(all)

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Association of neonatal serum immunoglobulin G1 concentration with health and performance in beef calves. / Dewell, Reneé D.; Hungerford, Laura L.; Keen, James; Laegreid, William W.; Griffin, D. Dee; Rupp, Gary P.; Grotelueschen, Dale M.

In: Journal of the American Veterinary Medical Association, Vol. 228, No. 6, 15.03.2006, p. 914-921.

Research output: Contribution to journalArticle

Dewell, Reneé D. ; Hungerford, Laura L. ; Keen, James ; Laegreid, William W. ; Griffin, D. Dee ; Rupp, Gary P. ; Grotelueschen, Dale M. / Association of neonatal serum immunoglobulin G1 concentration with health and performance in beef calves. In: Journal of the American Veterinary Medical Association. 2006 ; Vol. 228, No. 6. pp. 914-921.
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