Association of intracellular proteins with folded major histocompatibility complex class I molecules

Chantey R. Morris, Adrian J. Reber, Jason L. Petersen, Shanna E. Vargas, Joyce C Solheim

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) class I molecule is responsible for presenting peptide antigens at the cell surface for recognition by cytotoxic T lymphocytes. Several chaperone molecules interact with the MHC class I heavy chain and release when the MHC groove folds around peptide. Two additional proteins, invariant chain and amyloid precursor-like protein 2 (APLP2), interact specifically and stably with MHC class I molecules that have folded peptide-binding grooves. Invariant chain and APLP2 also affect MHC class I cell-surface expression, and so may play a part in MHC class I trafficking. Association of APLP2 with the MHC class I molecule appears to be regulated by a viral protein, the adenovirus E3/19K protein. Analysis of the interactions of these proteins with each other and with MHC class I will clarify how presentation of antigens by MHC class I is controlled by events that occur subsequent to MHC class I folding.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalImmunologic Research
Volume30
Issue number2
DOIs
StatePublished - Nov 8 2004

Fingerprint

Major Histocompatibility Complex
Proteins
Amyloid beta-Protein Precursor
Adenovirus E3 Proteins
Peptides
Antigen Presentation
Cytotoxic T-Lymphocytes
Viral Proteins
Surface Antigens

Keywords

  • Adenovirus E3/19K
  • Amyloid precursor-like protein 2
  • Antigen presentation
  • Antigen processing
  • Invariant chain
  • Major histocompatibility complex class I

ASJC Scopus subject areas

  • Immunology

Cite this

Association of intracellular proteins with folded major histocompatibility complex class I molecules. / Morris, Chantey R.; Reber, Adrian J.; Petersen, Jason L.; Vargas, Shanna E.; Solheim, Joyce C.

In: Immunologic Research, Vol. 30, No. 2, 08.11.2004, p. 171-179.

Research output: Contribution to journalReview article

Morris, Chantey R. ; Reber, Adrian J. ; Petersen, Jason L. ; Vargas, Shanna E. ; Solheim, Joyce C. / Association of intracellular proteins with folded major histocompatibility complex class I molecules. In: Immunologic Research. 2004 ; Vol. 30, No. 2. pp. 171-179.
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