Association of inflammatory and noninflammatory breast cancer with socioeconomic characteristics in the surveillance, epidemiology, and end results database, 2000-2007

Jennifer A. Schlichting, Amr S Soliman, Catherine Schairer, Mousumi Banerjee, Laura S. Rozek, David Schottenfeld, Joe B. Harford, Sofia D. Merajver

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Abstract

Background: Inflammatory breast cancer (IBC) is a rare and highly aggressive form of primary breast cancer. Little is known about the risk factors for IBC, specifically the association with socioeconomic position (SEP). Methods: The association between breast cancer type (IBC vs. non-IBC) with county-level SEP in the Surveillance, Epidemiology, and End Results database for cases diagnosed from 2000 to 2007 was examined. County-level SEP characteristics included metropolitan versus non-metropolitan residence, percentage below the poverty level, percentage less than high-school graduate, and an index combining the poverty and high-school variables. IBC and non-IBC age-adjusted incidence rates were calculated, stratified on SEP and race/ethnicity. The odds of IBC versus non-IBC given a particular SEP characteristic, adjusting for age and race/ethnicity, was examined through fitting of hierarchical logistic regression models (HLM). Results: Incidence rates for IBC generally increased as SEP decreased, whereas the opposite was found for non-IBC. HLM results showed that low SEP is associated with higher odds of IBC: highest (≥20%) versus lowest (<10%) persons below the poverty level [OR (95% confidence interval, CI) = 1.25 (1.09-1.43)]; highest (>28.76%) versus lowest (≤15.99%) persons less than high-school graduate [OR (95% CI) = 1.25 (1.10-1.42)]; and low SEP as measured by poverty-high school index versus high SEP [OR (95% CI) = 1.26 (1.11-1.44)]. Conclusion: Overall breast cancer has been found to be positively associated with SEP, whereas in this analysis, IBC was associated with decreasing SEP. Impact: Studies focused on understanding the disparity in IBC incidence, as well as interventions to eliminate these differences are needed.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2012

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Inflammatory Breast Neoplasms
Epidemiology
Databases
Breast Neoplasms
Poverty
Logistic Models
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Association of inflammatory and noninflammatory breast cancer with socioeconomic characteristics in the surveillance, epidemiology, and end results database, 2000-2007. / Schlichting, Jennifer A.; Soliman, Amr S; Schairer, Catherine; Banerjee, Mousumi; Rozek, Laura S.; Schottenfeld, David; Harford, Joe B.; Merajver, Sofia D.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 21, No. 1, 01.01.2012, p. 155-165.

Research output: Contribution to journalArticle

Schlichting, Jennifer A. ; Soliman, Amr S ; Schairer, Catherine ; Banerjee, Mousumi ; Rozek, Laura S. ; Schottenfeld, David ; Harford, Joe B. ; Merajver, Sofia D. / Association of inflammatory and noninflammatory breast cancer with socioeconomic characteristics in the surveillance, epidemiology, and end results database, 2000-2007. In: Cancer Epidemiology Biomarkers and Prevention. 2012 ; Vol. 21, No. 1. pp. 155-165.
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abstract = "Background: Inflammatory breast cancer (IBC) is a rare and highly aggressive form of primary breast cancer. Little is known about the risk factors for IBC, specifically the association with socioeconomic position (SEP). Methods: The association between breast cancer type (IBC vs. non-IBC) with county-level SEP in the Surveillance, Epidemiology, and End Results database for cases diagnosed from 2000 to 2007 was examined. County-level SEP characteristics included metropolitan versus non-metropolitan residence, percentage below the poverty level, percentage less than high-school graduate, and an index combining the poverty and high-school variables. IBC and non-IBC age-adjusted incidence rates were calculated, stratified on SEP and race/ethnicity. The odds of IBC versus non-IBC given a particular SEP characteristic, adjusting for age and race/ethnicity, was examined through fitting of hierarchical logistic regression models (HLM). Results: Incidence rates for IBC generally increased as SEP decreased, whereas the opposite was found for non-IBC. HLM results showed that low SEP is associated with higher odds of IBC: highest (≥20{\%}) versus lowest (<10{\%}) persons below the poverty level [OR (95{\%} confidence interval, CI) = 1.25 (1.09-1.43)]; highest (>28.76{\%}) versus lowest (≤15.99{\%}) persons less than high-school graduate [OR (95{\%} CI) = 1.25 (1.10-1.42)]; and low SEP as measured by poverty-high school index versus high SEP [OR (95{\%} CI) = 1.26 (1.11-1.44)]. Conclusion: Overall breast cancer has been found to be positively associated with SEP, whereas in this analysis, IBC was associated with decreasing SEP. Impact: Studies focused on understanding the disparity in IBC incidence, as well as interventions to eliminate these differences are needed.",
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AU - Schlichting, Jennifer A.

AU - Soliman, Amr S

AU - Schairer, Catherine

AU - Banerjee, Mousumi

AU - Rozek, Laura S.

AU - Schottenfeld, David

AU - Harford, Joe B.

AU - Merajver, Sofia D.

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