Association between herpes simplex virus type 1 and Helicobacter pylori in US adolescents

Lorena Baccaglini, Victor J. Schoenbach, Charles Poole, Rosemary G. McKaig, Joseph Ibrahim, Ralph S. Baric, Chris Wiesen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective. To understand how Helicobacter pylori infection is acquired and the role that herpes simplex virus type 1 (HSV-1) may have, we determined whether an association between HSV and H pylori exists at the individual level and for what reason. Study design. Data were collected from 1,090 participants aged 12-19 years during phase 1 (1988-1991) of the NHANES III. Generalized estimating equations were used to estimate prevalence ratios (PR). Results. The crude overall PR and 95% CI for H pylori seropositivity comparing HSV+ to HSV- individuals was 2.20 (1.69-2.85). In large urban households the PR adjusted for poverty level and race/ethnicity was twice that in small nonurban households (2.27 versus 1.15, respectively). Conclusions. Overall, HSV-1 seropositivity is associated with a higher H pylori seroprevalence. The negligible association found in some strata suggests that shared environmental factors or routes of transmission rather than biologic reasons may be primarily responsible for this association.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume101
Issue number1
DOIs
StatePublished - Jan 1 2006

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Pylorus
Human Herpesvirus 1
Helicobacter pylori
Nutrition Surveys
Seroepidemiologic Studies
Helicobacter Infections
Poverty

ASJC Scopus subject areas

  • Dentistry(all)
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery
  • Otorhinolaryngology
  • Oral Surgery

Cite this

Association between herpes simplex virus type 1 and Helicobacter pylori in US adolescents. / Baccaglini, Lorena; Schoenbach, Victor J.; Poole, Charles; McKaig, Rosemary G.; Ibrahim, Joseph; Baric, Ralph S.; Wiesen, Chris.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 101, No. 1, 01.01.2006, p. 63-69.

Research output: Contribution to journalArticle

Baccaglini, Lorena ; Schoenbach, Victor J. ; Poole, Charles ; McKaig, Rosemary G. ; Ibrahim, Joseph ; Baric, Ralph S. ; Wiesen, Chris. / Association between herpes simplex virus type 1 and Helicobacter pylori in US adolescents. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2006 ; Vol. 101, No. 1. pp. 63-69.
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