Assessment of genetic linkage and parent-of-origin effects on obesity

Yan Fang Guo, Hui Shen, Yong Jun Liu, Wei Wang, Dong Hai Xiong, Peng Xiao, Yao Zhong Liu, Lan Juan Zhao, Robert R. Recker, Hong Wen Deng

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28 Scopus citations

Abstract

Context: Obesity is a growing health care problem worldwide and is a major underlying risk factor for common diseases such as diabetes. Parent-of-origin effect has been reported to be involved in the development of obesity. But the genes with imprinting effects related to obesity are largely unknown. Objective: The objective of the study was to identify obesity-related genetic loci, both with and without imprinting effects. Design and Subjects: We conducted genome-wide linkage analyses for obesity with and without consideration of imprinting effects in a large sample including more than 4000 individuals. In addition to body mass index (BMI), we also used a more stringent and accurate obesity definition, which simultaneously considers BMI and percentage of fat mass (PFM) in a gender-specific manner. Simulations were performed to identify the genome-wide significant and suggestive significant thresholds. Results: In nonimprinted linkage analyses, we detected suggestive linkage at 2q31 (LOD = 2.23) and 16q22 (LOD = 1.87) for BMI and 2q37 (LOD = 2.23) for BMI and PFM. Interestingly, 2q37 also achieved a significant maternal linkage with BMI and PFM (LOD = 3.34) in imprinted linkage analyses. Imprinted linkage analyses revealed suggestive linkage evidence for BMI at three additional genomic regions, including 3p14 (LOD = 2.20, paternal), 3q24 (LOD = 1.97, maternal), and 19q13 (LOD = 1.81, maternal). Conclusion: We reported linkage and imprinting effects for obesity on several chromosome regions and suggested the potential importance of parent-of-origin effects and phenotype definition of obesity in delineating the genetic basis of obesity.

Original languageEnglish (US)
Pages (from-to)4001-4005
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number10
DOIs
StatePublished - Oct 2006

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Guo, Y. F., Shen, H., Liu, Y. J., Wang, W., Xiong, D. H., Xiao, P., Liu, Y. Z., Zhao, L. J., Recker, R. R., & Deng, H. W. (2006). Assessment of genetic linkage and parent-of-origin effects on obesity. Journal of Clinical Endocrinology and Metabolism, 91(10), 4001-4005. https://doi.org/10.1210/jc.2006-0549