Assessment of buprenorphine, carprofen, and their combination for postoperative analgesia in olive baboons (Papio anubis)

Sarah O. Allison, Lisa C. Halliday, Jeffrey A. French, Dmitri D. Novikov, Jeffrey D. Fortman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study compared the efficacy of buprenorphine, carprofen, and a combination of the 2 analgesics in female baboons. Physiologic and behavioral parameters were assessed at baseline and postoperatively for 6 d by use of continuous non-invasive physiologic monitoring and twice-daily videotaping. Prior to surgery, all animals received a pre-emptive dose of either 0.01 mg/kg buprenorphine intramuscularly, 2.2 mg/kg carprofen intramuscularly, or a combination of 0.01 mg/kg buprenorphine and 2.2 mg/kg carprofen intramuscularly. All animals in the carprofen (n = 4) and buprenorphine+carprofen (n = 4) treatment groups appeared to have sufficient analgesia. Three of 4 animals in the buprenorphine group had adequate analgesia. The fourth animal had an elevated heart rate and spent less time standing during the postoperative period. In this study, the use of carprofen or a combination of carprofen plus buprenorphine provided more reliable postoperative analgesia than buprenorphine alone.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalJournal of the American Association for Laboratory Animal Science
Volume46
Issue number3
StatePublished - May 1 2007

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Papio anubis
buprenorphine
analgesia
animals
Papio
analgesics
heart rate
surgery
monitoring
dosage

ASJC Scopus subject areas

  • Animal Science and Zoology

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Assessment of buprenorphine, carprofen, and their combination for postoperative analgesia in olive baboons (Papio anubis). / Allison, Sarah O.; Halliday, Lisa C.; French, Jeffrey A.; Novikov, Dmitri D.; Fortman, Jeffrey D.

In: Journal of the American Association for Laboratory Animal Science, Vol. 46, No. 3, 01.05.2007, p. 24-31.

Research output: Contribution to journalArticle

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