Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy: A report of two cases

Anthony W. Tolcher, Ruthann M. Giusti, Joyce A. O'Shaughnessy, Kenneth H. Cowan

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26 Scopus citations


The occurrence of arterial thrombosis reported in other breast cancer series has largely been confined to the upper extremities, ipsilateral to a previous mastectomy site and clinically manifest as cerebral vascular accidents. This case report describes 2 patients who experienced iliac artery thrombosis temporally related to receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) and dose-intensive chemotherapy for metastatic breast cancer. A review of the literature concerning arterial thrombosis as relevant to breast cancer treatment and GM-CSF is included.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalCancer Investigation
Issue number2
Publication statusPublished - Jan 1 1995


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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