Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy

A report of two cases

Anthony W. Tolcher, Ruthann M. Giusti, Joyce A. O'Shaughnessy, Kenneth H Cowan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The occurrence of arterial thrombosis reported in other breast cancer series has largely been confined to the upper extremities, ipsilateral to a previous mastectomy site and clinically manifest as cerebral vascular accidents. This case report describes 2 patients who experienced iliac artery thrombosis temporally related to receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) and dose-intensive chemotherapy for metastatic breast cancer. A review of the literature concerning arterial thrombosis as relevant to breast cancer treatment and GM-CSF is included.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalCancer Investigation
Volume13
Issue number2
DOIs
StatePublished - Jan 1 1995

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Granulocyte-Macrophage Colony-Stimulating Factor
Thrombosis
Breast Neoplasms
Drug Therapy
Iliac Artery
Mastectomy
Upper Extremity
Accidents
Blood Vessels
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy : A report of two cases. / Tolcher, Anthony W.; Giusti, Ruthann M.; O'Shaughnessy, Joyce A.; Cowan, Kenneth H.

In: Cancer Investigation, Vol. 13, No. 2, 01.01.1995, p. 188-192.

Research output: Contribution to journalArticle

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