Class I MHC heavy chains associate with many proteins in the endoplasmic reticulum, including TAP, calnexin, calreticulin, and the newly defined tapasin molecule. Recent studies have begun to resolve the nature of how these proteins interact with class I as well as the functional significance of each of these interactions. We propose here that TAP and tapasin are leading candidates to be highly specific chaperones for the class I molecule.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Immunology|
|Publication status||Published - Jan 15 1997|
ASJC Scopus subject areas
- Immunology and Allergy