Are Transporter Associated with Antigen Processing (TAP) and Tapasin Class I MHC Chaperones?

Joyce C. Solheim, Beatriz M. Carreno, Ted H. Hansen

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Class I MHC heavy chains associate with many proteins in the endoplasmic reticulum, including TAP, calnexin, calreticulin, and the newly defined tapasin molecule. Recent studies have begun to resolve the nature of how these proteins interact with class I as well as the functional significance of each of these interactions. We propose here that TAP and tapasin are leading candidates to be highly specific chaperones for the class I molecule.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalJournal of Immunology
Volume158
Issue number2
Publication statusPublished - Jan 15 1997

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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