Abstract
Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.
Original language | English (US) |
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Pages (from-to) | 1213-1216 |
Number of pages | 4 |
Journal | Journal of Pediatric Endocrinology and Metabolism |
Volume | 27 |
Issue number | 11-12 |
DOIs | |
State | Published - Nov 1 2014 |
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Keywords
- Celiac disease
- HDL
- lipids
- type 1 diabetes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only? / Jessup, Ashley B.; Law, Jennifer R.; Spagnoli, Anna.
In: Journal of Pediatric Endocrinology and Metabolism, Vol. 27, No. 11-12, 01.11.2014, p. 1213-1216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only?
AU - Jessup, Ashley B.
AU - Law, Jennifer R.
AU - Spagnoli, Anna
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.
AB - Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.
KW - Celiac disease
KW - HDL
KW - lipids
KW - type 1 diabetes
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U2 - 10.1515/jpem-2013-0464
DO - 10.1515/jpem-2013-0464
M3 - Article
C2 - 25153213
AN - SCOPUS:84964262405
VL - 27
SP - 1213
EP - 1216
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
SN - 0334-018X
IS - 11-12
ER -