Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only?

Ashley B. Jessup, Jennifer R. Law, Anna Spagnoli

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.

Original languageEnglish (US)
Pages (from-to)1213-1216
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume27
Issue number11-12
DOIs
StatePublished - Nov 1 2014

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Celiac Disease
Type 1 Diabetes Mellitus
Lipids
Endoscopy
Medical Records
Cardiovascular Diseases
Databases

Keywords

  • Celiac disease
  • HDL
  • lipids
  • type 1 diabetes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only? / Jessup, Ashley B.; Law, Jennifer R.; Spagnoli, Anna.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 27, No. 11-12, 01.11.2014, p. 1213-1216.

Research output: Contribution to journal › Article

Jessup, AB, Law, JR & Spagnoli, A 2014, 'Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only?', Journal of Pediatric Endocrinology and Metabolism, vol. 27, no. 11-12, pp. 1213-1216. https://doi.org/10.1515/jpem-2013-0464
Jessup AB, Law JR, Spagnoli A. Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only? Journal of Pediatric Endocrinology and Metabolism. 2014 Nov 1;27(11-12):1213-1216. https://doi.org/10.1515/jpem-2013-0464
Jessup, Ashley B. ; Law, Jennifer R. ; Spagnoli, Anna. / Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only?. In: Journal of Pediatric Endocrinology and Metabolism. 2014 ; Vol. 27, No. 11-12. pp. 1213-1216.
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abstract = "Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.",
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N2 - Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.

AB - Celiac disease (CD) is associated with type 1 diabetes mellitus (T1DM), which is known to be associated with abnormal lipid profiles. We aimed to examine the impact of CD on lipid profiles in persons with T1DM. Subjects with T1DM were identified by database and medical record review. Patients were classified as T1DM+CD or T1DM based on CD antibody and endoscopy results. The most recent (before age 20 years) non-fasting lipid panel (NFLP) prior to CD diagnosis for T1DM+CD subjects was compared to the most recent NFLP for T1DM subjects. Adjusted analysis showed T1DM+CD had lower HDL compared with T1DM (T1DM+CD 51.4 mg/dL, T1DM 62.2 mg/dL, p=0.017). There were no other differences in NFLP. In our sample, patients with T1DM+CD had lower HDL levels. Considering the increased cardiovascular disease risk of patients with T1DM, those who also have CD may be at even greater risk due to the association with lower HDL.

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