Approach to lipid screening as a risk marker for cardiovascular disease in pediatric patients with diabetes

Jennifer Rachel Law, Shipra Patel, Anna Spagnoli

Research output: Contribution to journalReview article

Abstract

Cardiovascular disease (CVD) is a well-known complication of diabetes mellitus (DM), and patients with DM are at an increased risk for early onset of CVD. Hyperglycemia is believed to be the primary mediator in premature development of atherosclerosis in patients with DM, but there are also derangements in cholesterol levels and inflammatory markers beyond the explanation of hyperglycemia. Although clinicians often screen for dyslipidemia as part of routine care for children and adolescents with DM, many do not feel comfortable treating this condition. Multiple guidelines exist to help clinicians with the prevention, screening, and treatment of CVD risk factors in pediatric patients with DM, but the guidelines do not always agree on screening intervals or medical treatment. Furthermore, the cost-effectiveness of medication use in this population has not been established. Research has advanced our understanding of the role of other biomarkers and radiologic studies of CVD risk, but these studies do not currently have a place in routine clinical practice. It is evident that the increased CVD risk in pediatric patients with DM is complex in origin and the optimal approach to managing dyslipidemia remains unclear. Therefore, an algorithm designed at the University of North Carolina (UNC), Division of Pediatric Endocrinology, is presented to help guide clinicians through screening and treatment of dyslipidemia in youth with DM.

Original languageEnglish (US)
Article numberArticle 47
JournalFrontiers in Endocrinology
Volume2
Issue numberOCT
DOIs
StatePublished - Dec 1 2011

Fingerprint

Diabetes Mellitus
Cardiovascular Diseases
Pediatrics
Lipids
Dyslipidemias
Hyperglycemia
Guidelines
Endocrinology
Diabetes Complications
Child Care
Cost-Benefit Analysis
Atherosclerosis
Therapeutics
Biomarkers
Cholesterol
Research
Population

Keywords

  • Cardiovascular disease
  • Cholesterol
  • Diabetes
  • Dyslipidemia
  • Statin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Approach to lipid screening as a risk marker for cardiovascular disease in pediatric patients with diabetes. / Law, Jennifer Rachel; Patel, Shipra; Spagnoli, Anna.

In: Frontiers in Endocrinology, Vol. 2, No. OCT, Article 47, 01.12.2011.

Research output: Contribution to journalReview article

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