Applications of miRNA technology for atherosclerosis

Hiroe Toba, Dolores Cortez, Merry L. Lindsey, Robert J. Chilton

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.

Original languageEnglish (US)
Article number386
JournalCurrent atherosclerosis reports
Volume16
Issue number2
DOIs
StatePublished - Feb 2014

Fingerprint

MicroRNAs
Atherosclerosis
Technology
Information Science
Physiological Phenomena
Gene Expression Regulation
Gene Silencing
Dyslipidemias
Insulin Resistance
Cardiovascular Diseases
Obesity
Biomarkers
Pathology
Research
Genes

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Diabetes
  • Hyperlipidemia
  • Insulin resistance
  • Matrix metalloproteinase
  • Metabolics
  • MicroRNA
  • Obesity
  • Proteomics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Applications of miRNA technology for atherosclerosis. / Toba, Hiroe; Cortez, Dolores; Lindsey, Merry L.; Chilton, Robert J.

In: Current atherosclerosis reports, Vol. 16, No. 2, 386, 02.2014.

Research output: Contribution to journalReview article

Toba, Hiroe ; Cortez, Dolores ; Lindsey, Merry L. ; Chilton, Robert J. / Applications of miRNA technology for atherosclerosis. In: Current atherosclerosis reports. 2014 ; Vol. 16, No. 2.
@article{499f06ee62b84fe6965b4572469c94e7,
title = "Applications of miRNA technology for atherosclerosis",
abstract = "MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.",
keywords = "Atherosclerosis, Cardiovascular disease, Diabetes, Hyperlipidemia, Insulin resistance, Matrix metalloproteinase, Metabolics, MicroRNA, Obesity, Proteomics",
author = "Hiroe Toba and Dolores Cortez and Lindsey, {Merry L.} and Chilton, {Robert J.}",
year = "2014",
month = "2",
doi = "10.1007/s11883-013-0386-9",
language = "English (US)",
volume = "16",
journal = "Current Atherosclerosis Reports",
issn = "1523-3804",
publisher = "Current Medicine Group",
number = "2",

}

TY - JOUR

T1 - Applications of miRNA technology for atherosclerosis

AU - Toba, Hiroe

AU - Cortez, Dolores

AU - Lindsey, Merry L.

AU - Chilton, Robert J.

PY - 2014/2

Y1 - 2014/2

N2 - MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.

AB - MicroRNAs (miRNAs) are a class of post-transcriptional regulators that provide a mechanism of gene silencing by translational repression or degradation of the targeted gene. Gene expression regulation by miRNAs is involved in most if not all physiological and pathophysiological processes. Atherosclerosis is a major cardiovascular disease pathology regulated by miRNAs. Recent miRNA profiling studies have implicated the potential use of miRNAs as biomarkers in patients with atherosclerosis, as both diagnostic and prognostic indicators. This review will discuss the clinical and basic science research information that has been gleaned regarding miRNA roles in dyslipidemia, diabetes, obesity, and insulin resistance which are the major stimulators for the development of atherosclerosis.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Diabetes

KW - Hyperlipidemia

KW - Insulin resistance

KW - Matrix metalloproteinase

KW - Metabolics

KW - MicroRNA

KW - Obesity

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=84891517825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891517825&partnerID=8YFLogxK

U2 - 10.1007/s11883-013-0386-9

DO - 10.1007/s11883-013-0386-9

M3 - Review article

C2 - 24395388

AN - SCOPUS:84891517825

VL - 16

JO - Current Atherosclerosis Reports

JF - Current Atherosclerosis Reports

SN - 1523-3804

IS - 2

M1 - 386

ER -