Apparent lower rates of streptococcal toxic shock syndrome and lower mortality in children with invasive group A streptococcal infections compared with adults

H. D. Davies, A. Matlow, S. R. Scriver, P. Schlievert, M. Lovgren, J. A. Talbot, D. E. Low

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Since 1985 there have been worldwide reports of increases in severe invasive Group A streptococcal (IGAS) infections. We reviewed the charts of all children with IGAS infections (defined as isolation of Group A streptococcus from a normally sterile site) presenting to our institution over a 7-year period (January, 1985, to December, 1991) and the literature. Streptococcal toxic shock syndrome required hypotension and multisystem organ involvement. Twenty-four patients (mean age, 4.96 ± 4.4 years) were identified with IGAS infection. One patient (presenting in 1989) met the criteria for probable streptococcal toxic shock syndrome and none died. Eight of 19 Group A streptococcal isolates tested were streptococcal pyrogenic exotoxin (SPE) A producers, most (90%) had the speC gene and all had the speB gene and produced the toxin. No M or T type predominated. The low rates of streptococcal toxic shock syndrome and fatalities among children with IGAS infection are consistent with other pediatric but not with adult series. The apparent differences in outcome of IGAS between children and adults were not explained by the virulence factors we examined and may warrant further investigation.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalPediatric Infectious Disease Journal
Volume13
Issue number1
StatePublished - Jan 1994

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Streptococcal Infections
Child Mortality
Septic Shock
Virulence Factors
Streptococcus
Hypotension
Genes
Pediatrics

Keywords

  • Group A streptococcal infections
  • Toxic shock syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Apparent lower rates of streptococcal toxic shock syndrome and lower mortality in children with invasive group A streptococcal infections compared with adults. / Davies, H. D.; Matlow, A.; Scriver, S. R.; Schlievert, P.; Lovgren, M.; Talbot, J. A.; Low, D. E.

In: Pediatric Infectious Disease Journal, Vol. 13, No. 1, 01.1994, p. 49-56.

Research output: Contribution to journalArticle

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