Apoptosis

Its functions and control in the ocular lens

L. Zhang, Q. Yan, J. P. Liu, L. J. Zou, J. Liu, S. Sun, M. Deng, L. Gong, W. K. Ji, David W Li

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The ocular lens is a non-vascular and non-innervated transparent organ that plays an important role in vision processing. This unique organ is derived from the embryonic ectoderm of the brain region through a complicated differentiation process in which apoptosis plays a key role. First, when the committed ectoderm becomes thickened and invaginated, the defined number of cells required to form the lens vesicle is partially determined by apoptosis. Second, separation of lens vesicle from the above corneal ectoderm is executed through apoptosis of the lens stalk cells. Finally, differentiation of the lens epithelial cells is controlled by the regulators, most of which are involved in control of apoptosis at multiple signaling steps. The lens is also characterized by continuous growth and differentiation in the adulthood. Through the different stages of growth and differentiation in the adult lens, various stress conditions can induce apoptosis of the lens epithelial cells, leading to eventual non-congenital cataractogenesis. The present review summarizes the current knowledge on the functions and regulators of apoptosis in the ocular lens.

Original languageEnglish (US)
Pages (from-to)864-875
Number of pages12
JournalCurrent Molecular Medicine
Volume10
Issue number9
DOIs
StatePublished - Dec 1 2010

Fingerprint

Crystalline Lens
Lenses
Apoptosis
Ectoderm
Epithelial Cells
Growth
Cell Count
Brain

Keywords

  • Apoptosis
  • Bak
  • Bax
  • Bcl-2
  • Caspase-3
  • Cataract
  • Development
  • Differentiation
  • Lens
  • P53
  • PP-1
  • Proliferation
  • a-crystallin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Zhang, L., Yan, Q., Liu, J. P., Zou, L. J., Liu, J., Sun, S., ... Li, D. W. (2010). Apoptosis: Its functions and control in the ocular lens. Current Molecular Medicine, 10(9), 864-875. https://doi.org/10.2174/156652410793937741

Apoptosis : Its functions and control in the ocular lens. / Zhang, L.; Yan, Q.; Liu, J. P.; Zou, L. J.; Liu, J.; Sun, S.; Deng, M.; Gong, L.; Ji, W. K.; Li, David W.

In: Current Molecular Medicine, Vol. 10, No. 9, 01.12.2010, p. 864-875.

Research output: Contribution to journalArticle

Zhang, L, Yan, Q, Liu, JP, Zou, LJ, Liu, J, Sun, S, Deng, M, Gong, L, Ji, WK & Li, DW 2010, 'Apoptosis: Its functions and control in the ocular lens', Current Molecular Medicine, vol. 10, no. 9, pp. 864-875. https://doi.org/10.2174/156652410793937741
Zhang L, Yan Q, Liu JP, Zou LJ, Liu J, Sun S et al. Apoptosis: Its functions and control in the ocular lens. Current Molecular Medicine. 2010 Dec 1;10(9):864-875. https://doi.org/10.2174/156652410793937741
Zhang, L. ; Yan, Q. ; Liu, J. P. ; Zou, L. J. ; Liu, J. ; Sun, S. ; Deng, M. ; Gong, L. ; Ji, W. K. ; Li, David W. / Apoptosis : Its functions and control in the ocular lens. In: Current Molecular Medicine. 2010 ; Vol. 10, No. 9. pp. 864-875.
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