Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3

Carla A. Wesson, James Deringer, Linda E. Liou, Kenneth W Bayles, Gregory A. Bohach, William R. Trumble

Research output: Contribution to journalArticle

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Abstract

In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves Caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1β by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.

Original languageEnglish (US)
Pages (from-to)2998-3001
Number of pages4
JournalInfection and Immunity
Volume68
Issue number5
DOIs
StatePublished - May 1 2000

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Caspase 8
Caspase 3
Staphylococcus aureus
Epithelial Cells
Apoptosis
T-Lymphocytes
Interleukin-1
Breast
Tumor Necrosis Factor-alpha
Cytokines
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3. / Wesson, Carla A.; Deringer, James; Liou, Linda E.; Bayles, Kenneth W; Bohach, Gregory A.; Trumble, William R.

In: Infection and Immunity, Vol. 68, No. 5, 01.05.2000, p. 2998-3001.

Research output: Contribution to journalArticle

Wesson, Carla A. ; Deringer, James ; Liou, Linda E. ; Bayles, Kenneth W ; Bohach, Gregory A. ; Trumble, William R. / Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3. In: Infection and Immunity. 2000 ; Vol. 68, No. 5. pp. 2998-3001.
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