ApcMin

A mouse model for intestinal and mammary tumorigenesis

A. R. Moser, C. Luongo, Karen A Gould, M. K. McNeley, A. R. Shoemaker, W. F. Dove

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Min (multiple intestinal neoplasia) is a mutant allele of the murine Apc (adenomatous polyposis coli) locus, encoding a nonsense mutation at codon 850. Like humans with germline mutations in APC, Min/+ mice are predisposed to intestinal adenoma formation. The number of adenomas is influenced by modifier loci carried by different inbred strains. One modifier locus, Mom-1 (modifier of Min-1), maps to distal chromosome 4. Intestinal tumours from both B6 (C57BL/6J) and hybrid Min/+ mice show extensive loss of the wild-type allele at Apc. B6 Min/+ female mice are predisposed to spontaneous mammary tumours. The incidence of both intestinal and mammary tumours can be increased in an age-specific manner by treatment with ethylnitrosourea (ENU). Min mice provide a good animal model for studying the role of Apc and interacting genes in the initiation and progression of intestinal and mammary tumorigenesis.

Original languageEnglish (US)
Pages (from-to)1061-1064
Number of pages4
JournalEuropean Journal of Cancer
Volume31
Issue number7-8
DOIs
StatePublished - Jan 1 1995

Fingerprint

Carcinogenesis
Breast
Neoplasms
Adenomatous Polyposis Coli
Adenoma
Alleles
Breast Neoplasms
APC Genes
Ethylnitrosourea
Chromosomes, Human, Pair 4
Germ-Line Mutation
Nonsense Codon
Codon
Animal Models
Incidence

Keywords

  • Apc (adenomatous polyposis coli)
  • Min (multiple intestinal neoplasia)
  • animal model
  • intestinal adenomas
  • mammary tumours
  • mouse

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Moser, A. R., Luongo, C., Gould, K. A., McNeley, M. K., Shoemaker, A. R., & Dove, W. F. (1995). ApcMin: A mouse model for intestinal and mammary tumorigenesis. European Journal of Cancer, 31(7-8), 1061-1064. https://doi.org/10.1016/0959-8049(95)00181-H

ApcMin : A mouse model for intestinal and mammary tumorigenesis. / Moser, A. R.; Luongo, C.; Gould, Karen A; McNeley, M. K.; Shoemaker, A. R.; Dove, W. F.

In: European Journal of Cancer, Vol. 31, No. 7-8, 01.01.1995, p. 1061-1064.

Research output: Contribution to journalArticle

Moser, AR, Luongo, C, Gould, KA, McNeley, MK, Shoemaker, AR & Dove, WF 1995, 'ApcMin: A mouse model for intestinal and mammary tumorigenesis', European Journal of Cancer, vol. 31, no. 7-8, pp. 1061-1064. https://doi.org/10.1016/0959-8049(95)00181-H
Moser, A. R. ; Luongo, C. ; Gould, Karen A ; McNeley, M. K. ; Shoemaker, A. R. ; Dove, W. F. / ApcMin : A mouse model for intestinal and mammary tumorigenesis. In: European Journal of Cancer. 1995 ; Vol. 31, No. 7-8. pp. 1061-1064.
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