Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats

Tao Sun, Wei He, Gang Hu, Ming Li

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Atypical antipsychotics are also used in the treatment of anxiety-related disorders. Clinical and preclinical evidence regarding their intrinsic anxiolytic efficacy has been mixed. In this study, we examined the potential anxiolytic-like effects of risperidone and olanzapine, and compared them with haloperidol, chlordiazepoxide (a prototype of sedative-anxiolytic drug) or citalopram (a selective serotonin reuptake inhibitor). We used a composite of two-way avoidance conditioning and acoustic startle reflex model and examined the effects of drug treatments during the acquisition phase (Experiment 1) or extinction phase (Experiments 2 and 3) on multiple measures of conditioned and unconditioned fear/anxiety-like responses. In Experiment 4, we further compared risperidone, olanzapine, haloperidol, citalopram and chlordiazepoxide in a standard elevated plus maze test. Results revealed three distinct anxiolytic-like profiles associated with risperidone, olanzapine and chlordiazepoxide. Risperidone, especially at 1.0. mg/kg, significantly decreased the number of avoidance responses, 22. kHz ultrasonic vocalization, avoidance conditioning-induced hyperthermia and startle reactivity, but did not affect defecations or time spent on the open arms. Olanzapine (2.0. mg/kg, sc) significantly decreased the number of avoidance responses, 22. kHz vocalization and amount of defecations, but it did not inhibit startle reactivity and time spent on the open arms. Chlordiazepoxide (10. mg/kg, ip) significantly decreased the number of 22. kHz vocalization, avoidance conditioning-induced hyperthermia and amount of defecations, and increased time spent on the open arms, but did not decrease avoidance responses or startle reactivity. Haloperidol and citalopram did not display any anxiolytic-like property in these tests. The results highlight the importance of using multiple measures of fear-related responses to delineate behavioral profiles of psychotherapeutic drugs.

Original languageEnglish (US)
Pages (from-to)298-307
Number of pages10
JournalPharmacology Biochemistry and Behavior
Volume95
Issue number3
DOIs
StatePublished - May 1 2010

Fingerprint

olanzapine
Risperidone
Anti-Anxiety Agents
Chlordiazepoxide
Fear
Rats
Citalopram
Defecation
Startle Reflex
Haloperidol
Induced Hyperthermia
Pharmaceutical Preparations
Drug therapy
Experiments
Serotonin Uptake Inhibitors
Anxiety Disorders
Hypnotics and Sedatives
Ultrasonics
Antipsychotic Agents
Anxiety

Keywords

  • 22kHz ultrasonic vocalizations
  • Chlordiazepoxide
  • Citalopram
  • Conditioned avoidance response
  • Elevated plus maze
  • Haloperidol
  • Olanzapine
  • Risperidone
  • Startle responses
  • Stress-induced hyperthermia

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats. / Sun, Tao; He, Wei; Hu, Gang; Li, Ming.

In: Pharmacology Biochemistry and Behavior, Vol. 95, No. 3, 01.05.2010, p. 298-307.

Research output: Contribution to journalArticle

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