Antitubercular natural products: Berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8- oxotetrahydrothalifendine, canadine, β-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2

Elmer J. Gentry, Hanuman B. Jampani, Ali Keshavarz-Shokri, Martha D. Morton, David Vander Velde, Hanumaiah Telikepalli, Lester A. Mitscher, Ribhi Shawar, Debbi Humble, William Baker

Research output: Contribution to journalArticle

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Abstract

Berberine (4) is responsible for the activity of an extract of a commercial root sample of Hydrastis canadensis against multiply drug resistant Mycobacterium tuberculosis. Two new quinic acid feruloyl esters, compounds 2 and 3, have been isolated from the same source along with canadine (1c), 8-oxotetrahydrothalifendine (1), and β-hydrastine (5). These were found to be inactive. The structures of the new compounds were elucidated from spectral (1H, 13C, HMQC, HMBC, and H-H COSY) and chemical evidences.

Original languageEnglish (US)
Pages (from-to)1187-1193
Number of pages7
JournalJournal of Natural Products
Volume61
Issue number10
DOIs
StatePublished - Oct 1 1998

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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