Antisocial alcoholism and serotonin-related polymorphisms

Association tests

Elizabeth M. Hill, Scott F Stoltenberg, Katherine Harris Bullard, Sheng Li, Robert A. Zucker, Marget Burmeister

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Central serotonin dysfunction appears to be related to a subtype of alcoholism with antisocial impulsive features (type II; antisocial alcoholism). The serotonergic deficit may be associated with greater impulsivity, which in turn facilitates both alcohol dependence and antisocial behavior. The present study tested association of antisocial impulsive alcoholism with candidate genes related to serotonergic neurotransmission, using families. Eight markers were assayed using polymerase chain reaction: tryptophan hydroxylase (intron 7), the serotonin transporter SLC6A4 (VNTR 9/12), HTTLPR, the three serotonin receptor types HTR1B (G861C), HTR2A (T102C) and HTR2C (Cys23Ser), monoamine oxidase A (T1460C), and (CA)n. Eligible probands had early age of onset of alcoholism, child conduct disorder, and two or more symptoms of adult Antisocial Personality Disorder. This sample included 35 probands, their parents, and some siblings (n = 116). Association tests were conducted using the Haplotype Relative Risk method for antisocial alcoholism diagnosis and the George-Elston regression method (the S.A.G.E. program ASSOC) for quantitative antisocial alcoholism severity. Haplotype Relative Risk analyses were not significant at the 0.05 level for any of the markers. Trends suggestive for future research occurred for tryptophan hydroxylase and HTR2A. Quantitative ASSOC analyses showed significant marker effects (P<0.05) for both monoamine oxidase A markers, which were in linkage disequilibrium. Antisocial alcoholism symptom severity was higher with monoamine oxidase A C homozygotes or hemizygotes, indicating that low monoamine oxidase activity may be important. Future studies are needed to examine joint and interactive effects of serotonin-related markers.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalPsychiatric Genetics
Volume12
Issue number3
DOIs
StatePublished - Sep 1 2002

Fingerprint

Alcoholism
Serotonin
Monoamine Oxidase
Tryptophan Hydroxylase
Haplotypes
Hemizygote
Antisocial Personality Disorder
Conduct Disorder
Serotonin Plasma Membrane Transport Proteins
Impulsive Behavior
Serotonin Receptors
Linkage Disequilibrium
Homozygote
Age of Onset
Synaptic Transmission
Introns
Siblings
Joints
Parents
Polymerase Chain Reaction

Keywords

  • Alcoholism
  • Antisocial personality disorder
  • Genetic association
  • Impulsivity
  • Monoamine oxidase
  • Serotonin

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Antisocial alcoholism and serotonin-related polymorphisms : Association tests. / Hill, Elizabeth M.; Stoltenberg, Scott F; Bullard, Katherine Harris; Li, Sheng; Zucker, Robert A.; Burmeister, Marget.

In: Psychiatric Genetics, Vol. 12, No. 3, 01.09.2002, p. 143-153.

Research output: Contribution to journalArticle

Hill, Elizabeth M. ; Stoltenberg, Scott F ; Bullard, Katherine Harris ; Li, Sheng ; Zucker, Robert A. ; Burmeister, Marget. / Antisocial alcoholism and serotonin-related polymorphisms : Association tests. In: Psychiatric Genetics. 2002 ; Vol. 12, No. 3. pp. 143-153.
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