Antineoplastic agents 370. Isolation and structure of dolastatin 18

George R. Pettit, Jun Ping Xu, Michael D. Williams, Fiona Hogan, Jean M. Schmidt, Ronald Cerny

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Bioassay-guided separation of cancer cell growth inhibitory fractions derived from the sea hare Dolabella auricularia obtained in Papua New Guinea led to isolation (1.51 x 10-7 % yield) of the new thiazole-containing peptide, dolastatin 18 (4). Structural determination was completed by employment of results from high-field (500 MHz) 2-D NMR experiments and tandem MS/MS mass spectral sequence analyses. Dolastatin 18 (4) was found to inhibit a selection of cancer cell lines among which GI50 0.39 μg/mL was found for the non-small cell lung cancer NCI-H460.

Original languageEnglish (US)
Pages (from-to)827-832
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number7
DOIs
StatePublished - Apr 8 1997

Fingerprint

Antineoplastic Agents
Cells
Hares
Thiazoles
Papua New Guinea
Cell Separation
Bioassay
Cell growth
Non-Small Cell Lung Carcinoma
Oceans and Seas
Biological Assay
Sequence Analysis
Neoplasms
Nuclear magnetic resonance
Cell Line
Peptides
Growth
Experiments
dolastatin 18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Antineoplastic agents 370. Isolation and structure of dolastatin 18. / Pettit, George R.; Xu, Jun Ping; Williams, Michael D.; Hogan, Fiona; Schmidt, Jean M.; Cerny, Ronald.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 7, 08.04.1997, p. 827-832.

Research output: Contribution to journalArticle

Pettit, George R. ; Xu, Jun Ping ; Williams, Michael D. ; Hogan, Fiona ; Schmidt, Jean M. ; Cerny, Ronald. / Antineoplastic agents 370. Isolation and structure of dolastatin 18. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 7. pp. 827-832.
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