Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp.

George R. Pettit, Rui Tan, Yoshitatsu Ichihara, Michael D. Williams, Dennis L. Doubek, Larry P. Tackett, Jean M. Schmidt, Ronald Cerny, Michael R. Boyd, John N A Hooper

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia (ED50values of 2.1 and 0.20 μg/ ml, respectively) and human cancer cell lines. The structures were established based on results of extensive tandem ms/ms and high-field (500-MHz) 2D 1H- and 13C-nmr analyses. All of the amino acid units (except Trp, not determined) were found to correspond to the (S)-configuration.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalJournal of Natural Products
Volume58
Issue number6
DOIs
StatePublished - Jun 1995

Fingerprint

Pacific Ocean
Lymphoid Leukemia
Cell growth
Porifera
Antineoplastic Agents
Cells
Amino Acids
Cell Line
Growth
Neoplasms
phakellistatin 11
phakellistatin 1
phakellistatin 10

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp. / Pettit, George R.; Tan, Rui; Ichihara, Yoshitatsu; Williams, Michael D.; Doubek, Dennis L.; Tackett, Larry P.; Schmidt, Jean M.; Cerny, Ronald; Boyd, Michael R.; Hooper, John N A.

In: Journal of Natural Products, Vol. 58, No. 6, 06.1995, p. 961-965.

Research output: Contribution to journalArticle

Pettit, George R. ; Tan, Rui ; Ichihara, Yoshitatsu ; Williams, Michael D. ; Doubek, Dennis L. ; Tackett, Larry P. ; Schmidt, Jean M. ; Cerny, Ronald ; Boyd, Michael R. ; Hooper, John N A. / Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from phakellia sp. In: Journal of Natural Products. 1995 ; Vol. 58, No. 6. pp. 961-965.
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