Antineoplastic agents 323. Isolation and structure of phakellistatin 6 from a Chuuk archipelago marine sponge

George R. Pettit, Jun Ping Xu, Zbigniew A. Cichacz, Michael D. Williams, Jean Charles Chapuis, Ronald Cerny

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Phakellistatin 6 (7), a trace (7.5 × 10-7% yield) constituent of the marine sponge Phakellia costata located in the Federated States of Micronesia has been found to significantly inhibit growth of certain human cancer cell lines (GI50, 0.1 to 0.01 μg/ml). The structure of phakellistatin 6 (7) was deduced as cyclo (Pro-Trp-Leu-Pro-Ile-Pro-Phe) employing a combination of MS/MS and high field (500 MHz) 2D-NMR procedures followed by chiral (all S amino acids) assignments using hydrolysis → derivatisation → chiral chromatographic techniques.

Original languageEnglish (US)
Pages (from-to)2677-2682
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number22
DOIs
Publication statusPublished - Nov 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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