Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5

George R. Pettit, Jun ping Xu, Zbigniew A. Cichacz, Michael D. Williams, Ann Christine Dorsaz, Daniel C. Brune, Michael R. Boyd, Ronald Cerny

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The Federated State of Micronesia (Chuuk) marine sponge Phakellia costada has been found to contain (9.6 x 10-6 % yield) a new human cancer cell growth inhibitor designated phakellistatin 5 (3). Structural elucidation was accomplished employing high resolution FAB tandem MS/MS and high field (500 MHz) 2D-NMR techniques. Extension of the NMR experiments over the temperature range -25 to 25°C allowed the principal solution conformation of phakellistatin 5 to be assigned (Figure 2). The absolute configuration was found to correspond to S-amino acid units except for R-Asn.

Original languageEnglish (US)
Pages (from-to)2091-2096
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number17
DOIs
StatePublished - Sep 8 1994

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Growth Inhibitors
Porifera
Antineoplastic Agents
Micronesia
Nuclear magnetic resonance
Conformations
Neoplasms
Amino Acids
Temperature
Experiments
phakellistatin 5
phakellistatin 3

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5. / Pettit, George R.; Xu, Jun ping; Cichacz, Zbigniew A.; Williams, Michael D.; Dorsaz, Ann Christine; Brune, Daniel C.; Boyd, Michael R.; Cerny, Ronald.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 17, 08.09.1994, p. 2091-2096.

Research output: Contribution to journalArticle

Pettit, George R. ; Xu, Jun ping ; Cichacz, Zbigniew A. ; Williams, Michael D. ; Dorsaz, Ann Christine ; Brune, Daniel C. ; Boyd, Michael R. ; Cerny, Ronald. / Antineoplastic agents 315. Isolation and structure of the marine sponge cancer cell growth inhibitor phakellistatin 5. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 17. pp. 2091-2096.
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