Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid

Keith M. Olsen, Tom E. Peddicord, G. Douglas Campbell, Mark Edmund Rupp

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Abstract

The antimicrobial activity of lidocaine in bronchoalveolar lavage fluid (BAL(f)) was investigated. Clinical respiratory isolates were added to BAL(f) suspensions containing lidocaine and to normal saline. The growth of two of four isolates of Streptococcus pneumoniae was significantly reduced in the presence of lidocaine-BAL(f) compared with controls in saline. Growth of Moraxella catarrhalis isolates was reduced in normal saline when compared with BAL(f) containing lidocaine. There was no effect upon the growth of Haemophilus influenzae, Pseudomonas aeruginosa and Candida albicans isolates. The recovery of isolates of S. pneumoniae may be reduced below the critical threshold of 105 cfu/mL during bronchoscopy when using lidocaine as a local anaesthetic.

Original languageEnglish (US)
Pages (from-to)217-219
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume45
Issue number2
DOIs
Publication statusPublished - Jan 1 2000

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ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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