Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae

Kimberly L. Bergman, Keith M. Olsen, Tom E. Peddicord, Paul D Fey, Mark Edmund Rupp

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

Original languageEnglish (US)
Pages (from-to)1291-1293
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number5
StatePublished - Jan 1 1999

Fingerprint

Azithromycin
Clarithromycin
Haemophilus influenzae
Streptococcus pneumoniae
Epithelial Cells
Macrolides
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

@article{0f1bbd69e2744a73b77f3bd9b486f866,
title = "Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae",
abstract = "The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.",
author = "Bergman, {Kimberly L.} and Olsen, {Keith M.} and Peddicord, {Tom E.} and Fey, {Paul D} and Rupp, {Mark Edmund}",
year = "1999",
month = "1",
day = "1",
language = "English (US)",
volume = "43",
pages = "1291--1293",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "5",

}

TY - JOUR

T1 - Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae

AU - Bergman, Kimberly L.

AU - Olsen, Keith M.

AU - Peddicord, Tom E.

AU - Fey, Paul D

AU - Rupp, Mark Edmund

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

AB - The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

UR - http://www.scopus.com/inward/record.url?scp=0032952413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032952413&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 1291

EP - 1293

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 5

ER -