The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.
|Original language||English (US)|
|Number of pages||3|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - May 1999|
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases