Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae

Kimberly L. Bergman, Keith M. Olsen, Tom E. Peddicord, Paul D Fey, Mark Edmund Rupp

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The antimicrobial activity of concentrations of selected macrolides found in epithelial cell lining fluid was investigated. Clarithromycin demonstrated greater potency and a significantly longer postantibiotic effect (PAE) than azithromycin against Streptococcus pneumoniae. Azithromycin displayed greater potency, faster killing, and a longer PAE than clarithromycin against Haemophilus influenzae. Drug concentrations in epithelial cell lining fluid similar to those found in tissue did not improve the synergistic potential of 14-hydroxy-clarithromycin and indicate that a maximal PAE may exist despite increasing concentrations of drug.

Original languageEnglish (US)
Pages (from-to)1291-1293
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number5
Publication statusPublished - May 1999

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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