Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

Rebecca J. Garten, C. Todd Davis, Colin A. Russell, Bo Shu, Stephen Lindstrom, Amanda Balish, Wendy M. Sessions, Xiyan Xu, Eugene Skepner, Varough Deyde, Margaret Okomo-Adhiambo, Larisa Gubareva, John Barnes, Catherine B. Smith, Shannon L. Emery, Michael J. Hillman, Pierre Rivailler, James Smagala, Miranda De Graaf, David F. Burke & 39 others Ron A M Fouchier, Claudia Pappas, Celia M. Alpuche-Aranda, Hugo López-Gatell, Hiram Olivera, Irma López, Christopher A. Myers, Dennis Faix, Patrick J. Blair, Cindy Yu, Kimberly M. Keene, P. David Dotson, David Boxrud, Anthony R. Sambol, Syed H. Abid, Kirsten St. George, Tammy Bannerman, Amanda L. Moore, David J. Stringer, Patricia Blevins, Gail J. Demmler-Harrison, Michele Ginsberg, Paula Kriner, Steve Waterman, Sandra Smole, Hugo F. Guevara, Edward A. Belongia, Patricia A. Clark, Sara T. Beatrice, Ruben Donis, Jacqueline Katz, Lyn Finelli, Carolyn B. Bridges, Michael Shaw, Daniel B. Jernigan, Timothy M. Uyeki, Derek J. Smith, Alexander I. Klimov, Nancy J. Cox

Research output: Contribution to journalArticle

1725 Citations (Scopus)

Abstract

Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalScience
Volume325
Issue number5937
DOIs
StatePublished - Jul 10 2009

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H1N1 Subtype Influenza A Virus
Swine
Viruses
Genes

ASJC Scopus subject areas

  • General

Cite this

Garten, R. J., Davis, C. T., Russell, C. A., Shu, B., Lindstrom, S., Balish, A., ... Cox, N. J. (2009). Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science, 325(5937), 197-201. https://doi.org/10.1126/science.1176225

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. / Garten, Rebecca J.; Davis, C. Todd; Russell, Colin A.; Shu, Bo; Lindstrom, Stephen; Balish, Amanda; Sessions, Wendy M.; Xu, Xiyan; Skepner, Eugene; Deyde, Varough; Okomo-Adhiambo, Margaret; Gubareva, Larisa; Barnes, John; Smith, Catherine B.; Emery, Shannon L.; Hillman, Michael J.; Rivailler, Pierre; Smagala, James; De Graaf, Miranda; Burke, David F.; Fouchier, Ron A M; Pappas, Claudia; Alpuche-Aranda, Celia M.; López-Gatell, Hugo; Olivera, Hiram; López, Irma; Myers, Christopher A.; Faix, Dennis; Blair, Patrick J.; Yu, Cindy; Keene, Kimberly M.; Dotson, P. David; Boxrud, David; Sambol, Anthony R.; Abid, Syed H.; St. George, Kirsten; Bannerman, Tammy; Moore, Amanda L.; Stringer, David J.; Blevins, Patricia; Demmler-Harrison, Gail J.; Ginsberg, Michele; Kriner, Paula; Waterman, Steve; Smole, Sandra; Guevara, Hugo F.; Belongia, Edward A.; Clark, Patricia A.; Beatrice, Sara T.; Donis, Ruben; Katz, Jacqueline; Finelli, Lyn; Bridges, Carolyn B.; Shaw, Michael; Jernigan, Daniel B.; Uyeki, Timothy M.; Smith, Derek J.; Klimov, Alexander I.; Cox, Nancy J.

In: Science, Vol. 325, No. 5937, 10.07.2009, p. 197-201.

Research output: Contribution to journalArticle

Garten, RJ, Davis, CT, Russell, CA, Shu, B, Lindstrom, S, Balish, A, Sessions, WM, Xu, X, Skepner, E, Deyde, V, Okomo-Adhiambo, M, Gubareva, L, Barnes, J, Smith, CB, Emery, SL, Hillman, MJ, Rivailler, P, Smagala, J, De Graaf, M, Burke, DF, Fouchier, RAM, Pappas, C, Alpuche-Aranda, CM, López-Gatell, H, Olivera, H, López, I, Myers, CA, Faix, D, Blair, PJ, Yu, C, Keene, KM, Dotson, PD, Boxrud, D, Sambol, AR, Abid, SH, St. George, K, Bannerman, T, Moore, AL, Stringer, DJ, Blevins, P, Demmler-Harrison, GJ, Ginsberg, M, Kriner, P, Waterman, S, Smole, S, Guevara, HF, Belongia, EA, Clark, PA, Beatrice, ST, Donis, R, Katz, J, Finelli, L, Bridges, CB, Shaw, M, Jernigan, DB, Uyeki, TM, Smith, DJ, Klimov, AI & Cox, NJ 2009, 'Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans', Science, vol. 325, no. 5937, pp. 197-201. https://doi.org/10.1126/science.1176225
Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A et al. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009 Jul 10;325(5937):197-201. https://doi.org/10.1126/science.1176225
Garten, Rebecca J. ; Davis, C. Todd ; Russell, Colin A. ; Shu, Bo ; Lindstrom, Stephen ; Balish, Amanda ; Sessions, Wendy M. ; Xu, Xiyan ; Skepner, Eugene ; Deyde, Varough ; Okomo-Adhiambo, Margaret ; Gubareva, Larisa ; Barnes, John ; Smith, Catherine B. ; Emery, Shannon L. ; Hillman, Michael J. ; Rivailler, Pierre ; Smagala, James ; De Graaf, Miranda ; Burke, David F. ; Fouchier, Ron A M ; Pappas, Claudia ; Alpuche-Aranda, Celia M. ; López-Gatell, Hugo ; Olivera, Hiram ; López, Irma ; Myers, Christopher A. ; Faix, Dennis ; Blair, Patrick J. ; Yu, Cindy ; Keene, Kimberly M. ; Dotson, P. David ; Boxrud, David ; Sambol, Anthony R. ; Abid, Syed H. ; St. George, Kirsten ; Bannerman, Tammy ; Moore, Amanda L. ; Stringer, David J. ; Blevins, Patricia ; Demmler-Harrison, Gail J. ; Ginsberg, Michele ; Kriner, Paula ; Waterman, Steve ; Smole, Sandra ; Guevara, Hugo F. ; Belongia, Edward A. ; Clark, Patricia A. ; Beatrice, Sara T. ; Donis, Ruben ; Katz, Jacqueline ; Finelli, Lyn ; Bridges, Carolyn B. ; Shaw, Michael ; Jernigan, Daniel B. ; Uyeki, Timothy M. ; Smith, Derek J. ; Klimov, Alexander I. ; Cox, Nancy J. / Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. In: Science. 2009 ; Vol. 325, No. 5937. pp. 197-201.
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title = "Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans",
abstract = "Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).",
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AU - Garten, Rebecca J.

AU - Davis, C. Todd

AU - Russell, Colin A.

AU - Shu, Bo

AU - Lindstrom, Stephen

AU - Balish, Amanda

AU - Sessions, Wendy M.

AU - Xu, Xiyan

AU - Skepner, Eugene

AU - Deyde, Varough

AU - Okomo-Adhiambo, Margaret

AU - Gubareva, Larisa

AU - Barnes, John

AU - Smith, Catherine B.

AU - Emery, Shannon L.

AU - Hillman, Michael J.

AU - Rivailler, Pierre

AU - Smagala, James

AU - De Graaf, Miranda

AU - Burke, David F.

AU - Fouchier, Ron A M

AU - Pappas, Claudia

AU - Alpuche-Aranda, Celia M.

AU - López-Gatell, Hugo

AU - Olivera, Hiram

AU - López, Irma

AU - Myers, Christopher A.

AU - Faix, Dennis

AU - Blair, Patrick J.

AU - Yu, Cindy

AU - Keene, Kimberly M.

AU - Dotson, P. David

AU - Boxrud, David

AU - Sambol, Anthony R.

AU - Abid, Syed H.

AU - St. George, Kirsten

AU - Bannerman, Tammy

AU - Moore, Amanda L.

AU - Stringer, David J.

AU - Blevins, Patricia

AU - Demmler-Harrison, Gail J.

AU - Ginsberg, Michele

AU - Kriner, Paula

AU - Waterman, Steve

AU - Smole, Sandra

AU - Guevara, Hugo F.

AU - Belongia, Edward A.

AU - Clark, Patricia A.

AU - Beatrice, Sara T.

AU - Donis, Ruben

AU - Katz, Jacqueline

AU - Finelli, Lyn

AU - Bridges, Carolyn B.

AU - Shaw, Michael

AU - Jernigan, Daniel B.

AU - Uyeki, Timothy M.

AU - Smith, Derek J.

AU - Klimov, Alexander I.

AU - Cox, Nancy J.

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