Antibiotics and antibiotic resistance in agroecosystems: State of the science

Jessica Williams-Nguyen, J. Brett Sallach, Shannon L Bartelt-Hunt, Alistair B. Boxall, Lisa M. Durso, Jean E. McLain, Randall S. Singer, Daniel D Snow, Julie L. Zilles

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

We propose a simple causal model depicting relationships involved in dissemination of antibiotics and antibiotic resistance in agroecosystems and potential effects on human health, functioning of natural ecosystems, and agricultural productivity. Available evidence for each causal link is briefly summarized, and key knowledge gaps are highlighted. A lack of quantitative estimates of human exposure to environmental bacteria, in general, and antibiotic-resistant bacteria, specifically, is a significant data gap hindering the assessment of effects on human health. The contribution of horizontal gene transfer to resistance in the environment and conditions that might foster the horizontal transfer of antibiotic resistance genes into human pathogens also need further research. Existing research has focused heavily on human health effects, with relatively little known about the effects of antibiotics and antibiotic resistance on natural and agricultural ecosystems. The proposed causal model is used to elucidate gaps in knowledge that must be addressed by the research community and may provide a useful starting point for the design and analysis of future research efforts.

Original languageEnglish (US)
Pages (from-to)394-406
Number of pages13
JournalJournal of Environmental Quality
Volume45
Issue number2
DOIs
StatePublished - Jan 1 2016

Fingerprint

antibiotic resistance
Antibiotics
agricultural ecosystem
antibiotics
Health
Ecosystems
bacterium
gene transfer
Bacteria
Gene transfer
pathogen
Pathogens
productivity
science
effect
gene
ecosystem
Genes
Productivity
human health

ASJC Scopus subject areas

  • Environmental Engineering
  • Water Science and Technology
  • Waste Management and Disposal
  • Pollution
  • Management, Monitoring, Policy and Law

Cite this

Williams-Nguyen, J., Brett Sallach, J., Bartelt-Hunt, S. L., Boxall, A. B., Durso, L. M., McLain, J. E., ... Zilles, J. L. (2016). Antibiotics and antibiotic resistance in agroecosystems: State of the science. Journal of Environmental Quality, 45(2), 394-406. https://doi.org/10.2134/jeq2015.07.0336

Antibiotics and antibiotic resistance in agroecosystems : State of the science. / Williams-Nguyen, Jessica; Brett Sallach, J.; Bartelt-Hunt, Shannon L; Boxall, Alistair B.; Durso, Lisa M.; McLain, Jean E.; Singer, Randall S.; Snow, Daniel D; Zilles, Julie L.

In: Journal of Environmental Quality, Vol. 45, No. 2, 01.01.2016, p. 394-406.

Research output: Contribution to journalArticle

Williams-Nguyen, J, Brett Sallach, J, Bartelt-Hunt, SL, Boxall, AB, Durso, LM, McLain, JE, Singer, RS, Snow, DD & Zilles, JL 2016, 'Antibiotics and antibiotic resistance in agroecosystems: State of the science', Journal of Environmental Quality, vol. 45, no. 2, pp. 394-406. https://doi.org/10.2134/jeq2015.07.0336
Williams-Nguyen, Jessica ; Brett Sallach, J. ; Bartelt-Hunt, Shannon L ; Boxall, Alistair B. ; Durso, Lisa M. ; McLain, Jean E. ; Singer, Randall S. ; Snow, Daniel D ; Zilles, Julie L. / Antibiotics and antibiotic resistance in agroecosystems : State of the science. In: Journal of Environmental Quality. 2016 ; Vol. 45, No. 2. pp. 394-406.
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