Antibacterial activity of Pyrrosia petiolosa ethyl acetate extract against Staphylococcus aureus by decreasing hla and sea virulence genes

Liju Song, Mei Cao, Chong Chen, Panpan Qi, Ningzhe Li, Daoyan Wu, Jingshan Peng, Xuege Wang, Mao Zhang, Guoku Hu, Jian Zhao

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Abstract

The aim of this study was to explore the antibacterial activity of Pyrrosia petiolosa ethyl acetate extract (PPEAE) against Staphylococcus aureus in vitro and analyse its chemical components by gas chromatograph-mass spectrometry. The results of anti-microbial assay revealed that PPEAE had strong inhibitory activity against S.aureus, with MIC and MBC of 7.8 and 15.6 mg/mL, respectively. The transcriptional levels of hla and sea were reduced to 14.33 and 46.39% at the MIC compared to the control. Analysing test result exhibited that eugenol made a great contribution to antibacterial activity. This experiment indicated that PPEAE had prominent antibacterial activity against S. aureus.

Original languageEnglish (US)
Pages (from-to)1347-1350
Number of pages4
JournalNatural Product Research
Volume31
Issue number11
DOIs
Publication statusPublished - Jan 1 2017

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Keywords

  • Pyrrosia petiolosa ethyl acetate extract (PPEAE)
  • Staphylococcus aureus
  • antibacterial activity
  • composition analysis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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