Anterograde transport of HSV-1 and HSV-2 in the visual system

Robert B. Norgren, John H. McLean, H. Curt Bubel, Arden Wander, David I. Bernstein, Michael N. Lehman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain Mclntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalBrain Research Bulletin
Volume28
Issue number3
DOIs
StatePublished - Mar 1992

Fingerprint

Human Herpesvirus 2
Human Herpesvirus 1
Simplexvirus
Intravitreal Injections
Retinitis
Neurons
Retinal Ganglion Cells
Herpesviridae
Cricetinae

Keywords

  • Anterograde
  • Herpes simplex virus (HSV)
  • Lateral geniculate nucleus
  • Superior colliculus
  • Suprachiasmatic nucleus
  • Transneuronal
  • Visual system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Norgren, R. B., McLean, J. H., Curt Bubel, H., Wander, A., Bernstein, D. I., & Lehman, M. N. (1992). Anterograde transport of HSV-1 and HSV-2 in the visual system. Brain Research Bulletin, 28(3), 393-399. https://doi.org/10.1016/0361-9230(92)90038-Y

Anterograde transport of HSV-1 and HSV-2 in the visual system. / Norgren, Robert B.; McLean, John H.; Curt Bubel, H.; Wander, Arden; Bernstein, David I.; Lehman, Michael N.

In: Brain Research Bulletin, Vol. 28, No. 3, 03.1992, p. 393-399.

Research output: Contribution to journalArticle

Norgren, RB, McLean, JH, Curt Bubel, H, Wander, A, Bernstein, DI & Lehman, MN 1992, 'Anterograde transport of HSV-1 and HSV-2 in the visual system', Brain Research Bulletin, vol. 28, no. 3, pp. 393-399. https://doi.org/10.1016/0361-9230(92)90038-Y
Norgren, Robert B. ; McLean, John H. ; Curt Bubel, H. ; Wander, Arden ; Bernstein, David I. ; Lehman, Michael N. / Anterograde transport of HSV-1 and HSV-2 in the visual system. In: Brain Research Bulletin. 1992 ; Vol. 28, No. 3. pp. 393-399.
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