Another view of the selective model of thymocyte selection

Susan H. Chan, Dominic Cosgrove, Caroline Waltzinger, Christophe Benoist, Diane Mathis

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I- and double-deficient mice provides data challenging it. There exists a significant population of CD4 single positive cells in class II-deficient animals that is intermediate in maturity between CD4+CD8+ and end-stage CD4+CD8- thymocytes and is selected on class I molecules; an equivalent CD8+CD4- population occurs in class I-deficient animals. We propose a selective model entailing two TCR-MHC molecule engagements: the first provokes random down-modulation of either CD4 or CD8 and a degree of differentiation; the second, requiring participation of the appropriate coreceptor, permits end-stage differentiation.

Original languageEnglish (US)
Pages (from-to)225-236
Number of pages12
JournalCell
Volume73
Issue number2
DOIs
StatePublished - Apr 23 1993

Fingerprint

Thymocytes
Animals
Molecules
Population
Cells
Modulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chan, S. H., Cosgrove, D., Waltzinger, C., Benoist, C., & Mathis, D. (1993). Another view of the selective model of thymocyte selection. Cell, 73(2), 225-236. https://doi.org/10.1016/0092-8674(93)90225-F

Another view of the selective model of thymocyte selection. / Chan, Susan H.; Cosgrove, Dominic; Waltzinger, Caroline; Benoist, Christophe; Mathis, Diane.

In: Cell, Vol. 73, No. 2, 23.04.1993, p. 225-236.

Research output: Contribution to journalArticle

Chan, SH, Cosgrove, D, Waltzinger, C, Benoist, C & Mathis, D 1993, 'Another view of the selective model of thymocyte selection', Cell, vol. 73, no. 2, pp. 225-236. https://doi.org/10.1016/0092-8674(93)90225-F
Chan, Susan H. ; Cosgrove, Dominic ; Waltzinger, Caroline ; Benoist, Christophe ; Mathis, Diane. / Another view of the selective model of thymocyte selection. In: Cell. 1993 ; Vol. 73, No. 2. pp. 225-236.
@article{3bc72f52e91d4657a29aa2c326fac9d4,
title = "Another view of the selective model of thymocyte selection",
abstract = "Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I- and double-deficient mice provides data challenging it. There exists a significant population of CD4 single positive cells in class II-deficient animals that is intermediate in maturity between CD4+CD8+ and end-stage CD4+CD8- thymocytes and is selected on class I molecules; an equivalent CD8+CD4- population occurs in class I-deficient animals. We propose a selective model entailing two TCR-MHC molecule engagements: the first provokes random down-modulation of either CD4 or CD8 and a degree of differentiation; the second, requiring participation of the appropriate coreceptor, permits end-stage differentiation.",
author = "Chan, {Susan H.} and Dominic Cosgrove and Caroline Waltzinger and Christophe Benoist and Diane Mathis",
year = "1993",
month = "4",
day = "23",
doi = "10.1016/0092-8674(93)90225-F",
language = "English (US)",
volume = "73",
pages = "225--236",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - Another view of the selective model of thymocyte selection

AU - Chan, Susan H.

AU - Cosgrove, Dominic

AU - Waltzinger, Caroline

AU - Benoist, Christophe

AU - Mathis, Diane

PY - 1993/4/23

Y1 - 1993/4/23

N2 - Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I- and double-deficient mice provides data challenging it. There exists a significant population of CD4 single positive cells in class II-deficient animals that is intermediate in maturity between CD4+CD8+ and end-stage CD4+CD8- thymocytes and is selected on class I molecules; an equivalent CD8+CD4- population occurs in class I-deficient animals. We propose a selective model entailing two TCR-MHC molecule engagements: the first provokes random down-modulation of either CD4 or CD8 and a degree of differentiation; the second, requiring participation of the appropriate coreceptor, permits end-stage differentiation.

AB - Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I- and double-deficient mice provides data challenging it. There exists a significant population of CD4 single positive cells in class II-deficient animals that is intermediate in maturity between CD4+CD8+ and end-stage CD4+CD8- thymocytes and is selected on class I molecules; an equivalent CD8+CD4- population occurs in class I-deficient animals. We propose a selective model entailing two TCR-MHC molecule engagements: the first provokes random down-modulation of either CD4 or CD8 and a degree of differentiation; the second, requiring participation of the appropriate coreceptor, permits end-stage differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0027153897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027153897&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(93)90225-F

DO - 10.1016/0092-8674(93)90225-F

M3 - Article

C2 - 8097430

AN - SCOPUS:0027153897

VL - 73

SP - 225

EP - 236

JO - Cell

JF - Cell

SN - 0092-8674

IS - 2

ER -