Another really, really big virus

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Viruses with genomes larger than 300 kb and up to 1.2 Mb, which encode hundreds of proteins, are being discovered and characterized with increasing frequency. Most, but not all, of these large viruses (often referred to as giruses) infect protists that live in aqueous environments. Bioinformatic analyses of metagenomes of aqueous samples indicate that large DNA viruses are quite common in nature and await discovery. One issue that is perhaps not appreciated by the virology community is that large viruses, even those classified in the same family, can differ significantly in morphology, lifestyle, and gene complement. This brief commentary, which will mention some of these unique properties, was stimulated by the characterization of the newest member of this club, virus CroV (Fischer, M.G.; Allen, M.J.; Wilson, W.H.; Suttle, C.A. Giant virus with a remarkable complement of genes infects marine zooplankton. Proc. Natl. Acad. Sci. USA 2010, 107, 19508-19513 [1]). CroV has a 730 kb genome (with ~544 protein-encoding genes) and infects the marine microzooplankton Cafeteria roenbergensis producing a lytic infection.

Original languageEnglish (US)
Pages (from-to)32-46
Number of pages15
JournalViruses
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2011

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Viruses
Metagenome
Genome
Zooplankton
Virology
DNA Viruses
Computational Biology
Genes
Life Style
Proteins
Infection
Giant Viruses

Keywords

  • Giruses
  • Huge viruses
  • NCLDV

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Another really, really big virus. / Van Etten, James L.

In: Viruses, Vol. 3, No. 1, 01.01.2011, p. 32-46.

Research output: Contribution to journalArticle

Van Etten, James L. / Another really, really big virus. In: Viruses. 2011 ; Vol. 3, No. 1. pp. 32-46.
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