Angiotensin in the hemodynamic response to chronic nephron obstruction

Pamela K Carmines, G. A. Tanner

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Abstract

Microsphere techniques were employed to investigate the role of intrarenal angiotensin generation in producing the arteriolar constriction associated with 24-h tubular obstruction in rats. In each animal, glomerular blood flow (GBF) and nephron vascular resistance were determined for normal and oil-blocked superficial cortical nephrons. In 17 control rats, GBF of normal and blocked nephrons averaged 226 ± 12 and 130 ± 9 nl/min, respectively (P < 0.001). Captopril treatment in five rats (10 mg/kg orally) improved GBF to blocked nephrons to 252 ± 31 nl/min. Saralasin treatment in six rats (10 μg·kg-1·min-1 i.v.) lessened the difference between GBF of normal and obstructed nephrons. In six rats subjected to a high salt intake and deoxycorticosterone injections, GBF to obstructed nephrons was improved to 181 ± 21 nl/min. Since both pharmacologic interruption of angiotensin activity and renin suppression were associated with improved GBF of blocked nephrons, these observations support a role for angiotensin as a local factor controlling glomerular hemodynamics of chronically obstructed nephrons.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume14
Issue number1
StatePublished - Jan 1 1983

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Nephrons
Angiotensins
Hemodynamics
Saralasin
Desoxycorticosterone
Captopril
Microspheres
Renin
Constriction
Vascular Resistance
Oils
Salts
Injections
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

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