Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy

M. V. Raynolds, M. R. Bristow, E. W. Bush, W. T. Abraham, B. D. Lowes, L. S. Zisman, C. S. Taft, M. B. Perryman

Research output: Contribution to journalArticle

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Abstract

Summary. Polymorphism in the angiotensin-converting enzyme (ACE) gene has been shown to correlate with circulating ACE concentrations, and also to be an independent risk factor for the development of myocardial infarction, particularly in men thought to be at low risk by standard criteria. We determined the genotypes of individuals with end-stage heart failure due to either ischaemic dilated cardiomyopathy (102) or idiopathic dilated cardiomyopathy (112) and compared these to organ donors with normally functioning hearts (79). Genotypes were determined by the polymerase chain reaction with oligonucleotide primers flanking the polymorphic region in intron 16 of the ACE gene to amplify template DNA isolated from patients. Compared with the DD frequency in the control population, the frequency of the ACE DD genotype was 48% higher in individuals with idiopathic dilated cardiomyopathy (p=0·008) and 63% higher in subjects with ischaemic cardiomyopathy (p=0·008), suggesting that an ACE gene variant may contribute to the pathogenesis of both types of cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)1073-1075
Number of pages3
JournalThe Lancet
Volume342
Issue number8879
DOIs
StatePublished - Oct 30 1993

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Dilated Cardiomyopathy
Peptidyl-Dipeptidase A
Genotype
Cardiomyopathies
Genes
DNA Primers
Introns
Heart Failure
Myocardial Infarction
Tissue Donors
Polymerase Chain Reaction
DNA
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Raynolds, M. V., Bristow, M. R., Bush, E. W., Abraham, W. T., Lowes, B. D., Zisman, L. S., ... Perryman, M. B. (1993). Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. The Lancet, 342(8879), 1073-1075. https://doi.org/10.1016/0140-6736(93)92061-W

Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. / Raynolds, M. V.; Bristow, M. R.; Bush, E. W.; Abraham, W. T.; Lowes, B. D.; Zisman, L. S.; Taft, C. S.; Perryman, M. B.

In: The Lancet, Vol. 342, No. 8879, 30.10.1993, p. 1073-1075.

Research output: Contribution to journalArticle

Raynolds, MV, Bristow, MR, Bush, EW, Abraham, WT, Lowes, BD, Zisman, LS, Taft, CS & Perryman, MB 1993, 'Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy', The Lancet, vol. 342, no. 8879, pp. 1073-1075. https://doi.org/10.1016/0140-6736(93)92061-W
Raynolds, M. V. ; Bristow, M. R. ; Bush, E. W. ; Abraham, W. T. ; Lowes, B. D. ; Zisman, L. S. ; Taft, C. S. ; Perryman, M. B. / Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. In: The Lancet. 1993 ; Vol. 342, No. 8879. pp. 1073-1075.
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AU - Lowes, B. D.

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AB - Summary. Polymorphism in the angiotensin-converting enzyme (ACE) gene has been shown to correlate with circulating ACE concentrations, and also to be an independent risk factor for the development of myocardial infarction, particularly in men thought to be at low risk by standard criteria. We determined the genotypes of individuals with end-stage heart failure due to either ischaemic dilated cardiomyopathy (102) or idiopathic dilated cardiomyopathy (112) and compared these to organ donors with normally functioning hearts (79). Genotypes were determined by the polymerase chain reaction with oligonucleotide primers flanking the polymorphic region in intron 16 of the ACE gene to amplify template DNA isolated from patients. Compared with the DD frequency in the control population, the frequency of the ACE DD genotype was 48% higher in individuals with idiopathic dilated cardiomyopathy (p=0·008) and 63% higher in subjects with ischaemic cardiomyopathy (p=0·008), suggesting that an ACE gene variant may contribute to the pathogenesis of both types of cardiomyopathy.

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