Aneurysmal subarachnoid hemorrhage in patients taking direct oral anticoagulants: A case series and discussion of management

Joseph H. McMordie, Andrew P. Gard, Daniel L Surdell, William E Thorell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Direct oral anticoagulants are becoming more commonplace for the treatment of nonvalvular atrial fibrillation and deep vein thrombosis. Unfortunately, effective reversal agents are not widely available limiting options for neurosurgical intervention during active anticoagulation. We report a case series of 3 patients treated for aneurysmal subarachnoid hemorrhage while taking direct oral anticoagulants. All three underwent open surgical clipping after adequate time was allowed for drug metabolism. Decision-making must take into account timing of intervention, drug half-life, and currently available reversal agents.

Original languageEnglish (US)
Pages (from-to)65-67
Number of pages3
JournalInterdisciplinary Neurosurgery: Advanced Techniques and Case Management
Volume11
DOIs
StatePublished - Mar 2018

Fingerprint

Subarachnoid Hemorrhage
Anticoagulants
Venous Thrombosis
Pharmaceutical Preparations
Atrial Fibrillation
Half-Life
Decision Making
Therapeutics

Keywords

  • Aneurysmal subarachnoid hemorrhage
  • Direct oral anticoagulant
  • Prothrombin complex concentrate

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

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