10 Citations (Scopus)

Abstract

Breast cancer is the most common cause of cancer death in women worldwide. Rates vary about fivefold around the world, but they are increasing in regions that until recently had low rates of disease. Despite the numerous uncertainties surrounding the etiology of breast cancer, intensive epidemiological, clinical, and genetic studies have identified a number of biologic and social traits as risk factors associated with breast cancer. Principal among them are the evidence of BRCA1 and BRCA2 susceptibility genes, familial history of breast cancer, age, higher socioeconomic status, ionizing radiation, tallness in adult life, alcohol consumption, and a variety of hormone and metabolic factors. Among the hormonal influences, a relevant etiological function has been ascribed to elevated levels of estrogens, their active metabolites, and androgens. These endocrine factors may represent future targets for breast cancer prevention.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalNutrition and cancer
Volume56
Issue number2
DOIs
StatePublished - Dec 1 2006

Fingerprint

androgens
breast neoplasms
Androgens
estrogens
etiology
Estrogens
Breast Neoplasms
BRCA2 Gene
Ionizing Radiation
Social Class
Alcohol Drinking
Uncertainty
Cause of Death
socioeconomic status
ionizing radiation
Hormones
risk factors
uncertainty
hormones
metabolites

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Androgens and estrogens in the etiology and prevention of breast cancer. / Muti, Paola; Rogan, Eleanor G; Cavalieri, Ercole.

In: Nutrition and cancer, Vol. 56, No. 2, 01.12.2006, p. 247-252.

Research output: Contribution to journalArticle

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