Anatomical organization of excitatory amino acid receptors and their pathways

Carl W. Cotman, Daniel T. Monaghan, Ole P. Ottersen, Jon Storm-Mathisen

Research output: Contribution to journalReview article

690 Citations (Scopus)

Abstract

Synapses that employ excitatory amino acids (EAA) as their neurotransmitter use multiple combinations of receptors, apparently yielding different functional properties. The most well-characterized receptor class, the N-methyl-d-aspartate (NMDA) receptor, is found throughout the brain but primarily in telencephalic regions. Phencyclidine and glycine binding sites, which interact allosterically with NMDA receptors, have almost identical distributions. NMDA sites also extensively overlap with the quisqualate excitatory amino acid receptor class, but are less often found co-localized with the kainate receptor class. Evidence obtained with presynaptic markers - high affinity glutamate or aspartate uptake, Ca2+-dependent release, and glutamate and aspartate contents - each indicate that EAA are major transmitters of corticocortical, corticofugal, and sensory systems. Recent advances in the histological analysis of these markers are now providing a more detailed map of the excitatory amino acid system and this anatomical map appears to correspond to the distribution of the sum of the receptors. Thus the receptor systems may represent distinct, anatomically-organized, subsystems of excitatory amino acid-mediated neurotransmission.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalTrends in Neurosciences
Volume10
Issue number7
DOIs
StatePublished - Jul 1987

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Excitatory Amino Acids
Glutamate Receptors
Aspartic Acid
Glutamic Acid
Quisqualic Acid
Kainic Acid Receptors
Phencyclidine
Telencephalon
Synaptic Transmission
Synapses
Glycine
Neurotransmitter Agents
Binding Sites
Brain
aspartic acid receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anatomical organization of excitatory amino acid receptors and their pathways. / Cotman, Carl W.; Monaghan, Daniel T.; Ottersen, Ole P.; Storm-Mathisen, Jon.

In: Trends in Neurosciences, Vol. 10, No. 7, 07.1987, p. 273-280.

Research output: Contribution to journalReview article

Cotman, Carl W. ; Monaghan, Daniel T. ; Ottersen, Ole P. ; Storm-Mathisen, Jon. / Anatomical organization of excitatory amino acid receptors and their pathways. In: Trends in Neurosciences. 1987 ; Vol. 10, No. 7. pp. 273-280.
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