Analysis of the clinical features and prognostic factors of primary thyroid lymphoma

Yun Hou, Hua Qing Wang, Kai Fu, Xian Ming Liu, Li Hua Qiu, Hui Lai Zhang, Zheng Zi Qian, Wei Li, Lan Fang Li, Xi Shan Hao

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the clinical features and prognostic factors of primary thyroid lymphoma. Methods: Records of 44 patients with pathologically confirmed primary thyroid lymphoma were reviewed. Detailed clinical and laboratory data were included in univariate analysis, and statistically significant factors in univariate analysis were then included in multivariate analysis. Results: In univariate analysis, Ann Arbor stage, performance status, IPI, number of extra-lymphatic site, B symptoms, Hb, LDH and β2-MG level, therapy model, histology type and tumor mass were found to be the prognostic factors associated with overall survival in primary thyroid lymphoma. In multivariate analysis, performance status, IPI, LDH, β2-MG level, histology type, and tumor mass were independent prognostic factors of overall survival. Conclusion: Performance status, IPI, LDH and β2-MG level, histology type and tumor mass were demonstrated as independent prognostic factors of the overall survival in primary thyroid lymphoma.

Original languageEnglish (US)
JournalJournal of Leukemia and Lymphoma
Volume19
Issue number1
DOIs
StatePublished - Jan 1 2010

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Lymphoma
Thyroid Gland
Histology
Survival
Multivariate Analysis
Neoplasms
lactate dehydrogenase 2
Therapeutics

Keywords

  • Lymphoma
  • Prognosis
  • Thyroid neoplasms

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Analysis of the clinical features and prognostic factors of primary thyroid lymphoma. / Hou, Yun; Wang, Hua Qing; Fu, Kai; Liu, Xian Ming; Qiu, Li Hua; Zhang, Hui Lai; Qian, Zheng Zi; Li, Wei; Li, Lan Fang; Hao, Xi Shan.

In: Journal of Leukemia and Lymphoma, Vol. 19, No. 1, 01.01.2010.

Research output: Contribution to journalArticle

Hou, Yun ; Wang, Hua Qing ; Fu, Kai ; Liu, Xian Ming ; Qiu, Li Hua ; Zhang, Hui Lai ; Qian, Zheng Zi ; Li, Wei ; Li, Lan Fang ; Hao, Xi Shan. / Analysis of the clinical features and prognostic factors of primary thyroid lymphoma. In: Journal of Leukemia and Lymphoma. 2010 ; Vol. 19, No. 1.
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AU - Wang, Hua Qing

AU - Fu, Kai

AU - Liu, Xian Ming

AU - Qiu, Li Hua

AU - Zhang, Hui Lai

AU - Qian, Zheng Zi

AU - Li, Wei

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AB - Objective: To investigate the clinical features and prognostic factors of primary thyroid lymphoma. Methods: Records of 44 patients with pathologically confirmed primary thyroid lymphoma were reviewed. Detailed clinical and laboratory data were included in univariate analysis, and statistically significant factors in univariate analysis were then included in multivariate analysis. Results: In univariate analysis, Ann Arbor stage, performance status, IPI, number of extra-lymphatic site, B symptoms, Hb, LDH and β2-MG level, therapy model, histology type and tumor mass were found to be the prognostic factors associated with overall survival in primary thyroid lymphoma. In multivariate analysis, performance status, IPI, LDH, β2-MG level, histology type, and tumor mass were independent prognostic factors of overall survival. Conclusion: Performance status, IPI, LDH and β2-MG level, histology type and tumor mass were demonstrated as independent prognostic factors of the overall survival in primary thyroid lymphoma.

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