Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

Xiwei Zheng, Michelle J. Yoo, David S. Hage

Research output: Contribution to journalArticle

20 Scopus citations


A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

Original languageEnglish (US)
Pages (from-to)6262-6265
Number of pages4
Issue number21
StatePublished - Nov 7 2013


ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this