Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

Xiwei Zheng, Michelle J. Yoo, David S. Hage

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

Original languageEnglish (US)
Pages (from-to)6262-6265
Number of pages4
JournalAnalyst
Volume138
Issue number21
DOIs
StatePublished - Nov 7 2013

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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