Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

Xiwei Zheng, Michelle J. Yoo, David S Hage

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

Original languageEnglish (US)
Pages (from-to)6262-6265
Number of pages4
JournalAnalyst
Volume138
Issue number21
DOIs
StatePublished - Nov 7 2013

Fingerprint

Affinity chromatography
Enantiomers
Affinity Chromatography
chromatography
serum
drug
Proteins
protein
Warfarin
Serum Albumin
Pharmaceutical Preparations
Carrier Proteins
Serum
analysis
method

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this

Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography. / Zheng, Xiwei; Yoo, Michelle J.; Hage, David S.

In: Analyst, Vol. 138, No. 21, 07.11.2013, p. 6262-6265.

Research output: Contribution to journalArticle

@article{11bd3960e6ab417e8e665c15ce26e1c1,
title = "Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography",
abstract = "A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.",
author = "Xiwei Zheng and Yoo, {Michelle J.} and Hage, {David S}",
year = "2013",
month = "11",
day = "7",
doi = "10.1039/c3an01315d",
language = "English (US)",
volume = "138",
pages = "6262--6265",
journal = "The Analyst",
issn = "0003-2654",
publisher = "Royal Society of Chemistry",
number = "21",

}

TY - JOUR

T1 - Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography

AU - Zheng, Xiwei

AU - Yoo, Michelle J.

AU - Hage, David S

PY - 2013/11/7

Y1 - 2013/11/7

N2 - A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

AB - A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.

UR - http://www.scopus.com/inward/record.url?scp=84885010429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885010429&partnerID=8YFLogxK

U2 - 10.1039/c3an01315d

DO - 10.1039/c3an01315d

M3 - Article

VL - 138

SP - 6262

EP - 6265

JO - The Analyst

JF - The Analyst

SN - 0003-2654

IS - 21

ER -