Analysis of Bisulfite Via a Nitro Derivative of Cyanine-3 (NCy3) in the Microfluidic Channel

Haley A. Houtwed, Meng Xie, Aatiya Ahmad, Cody D. Masters, Melissa M. Davison, Kristy Kounovsky-Shafer, Haishi Cao

Research output: Contribution to journalArticle

Abstract

NCy3, a derivative of Cyanine 3 with a nitro substituent, showed a high reactivity to bisulfite in aqueous media, instantly leading to ratiometric change of absorption spectra and significant fluorescence quenching. Applied in the microfluidic channel, NCy3 functionalize as a sensitive approach for quantitative detection of bisulfite, particularly for samples with a small volume.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalJournal of Fluorescence
Volume29
Issue number3
DOIs
StatePublished - May 15 2019

Fingerprint

leading medium
Microfluidics
Derivatives
Fluorescence
Absorption spectra
Quenching
hydrogen sulfite

Keywords

  • Bisulfite sensor
  • Cyanine dye
  • Microfluidic channel
  • Nitration

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Psychology
  • Social Sciences (miscellaneous)
  • Sociology and Political Science
  • Spectroscopy
  • Clinical Biochemistry
  • Law

Cite this

Analysis of Bisulfite Via a Nitro Derivative of Cyanine-3 (NCy3) in the Microfluidic Channel. / Houtwed, Haley A.; Xie, Meng; Ahmad, Aatiya; Masters, Cody D.; Davison, Melissa M.; Kounovsky-Shafer, Kristy; Cao, Haishi.

In: Journal of Fluorescence, Vol. 29, No. 3, 15.05.2019, p. 523-529.

Research output: Contribution to journalArticle

Houtwed, Haley A. ; Xie, Meng ; Ahmad, Aatiya ; Masters, Cody D. ; Davison, Melissa M. ; Kounovsky-Shafer, Kristy ; Cao, Haishi. / Analysis of Bisulfite Via a Nitro Derivative of Cyanine-3 (NCy3) in the Microfluidic Channel. In: Journal of Fluorescence. 2019 ; Vol. 29, No. 3. pp. 523-529.
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