Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis

J. B. Weinberg, S. J. Hasstedt, M. H. Skolnick, W. J. Kimberling, B. Baty

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and 58 were typed for four electrophoretic enzyme markers. Likelihood analysis of the pedigree data confirmed independent dominant inheritance for elliptocytosis and lipomatosis. BFPSTS appears dominant, but the analysis was inconclusive. No linkages were found between any disease gene and any marker gene. Two female pedigree members with BFPSTS developed systemic lupus erythematosus, a finding in agreement with the previously described association. The analysis did not lead to any conclusions about the causal relationship between the two traits.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalAmerican journal of medical genetics
Volume5
Issue number1
DOIs
StatePublished - Dec 1 1980

Fingerprint

Lipoma
Serologic Tests
Syphilis
Pedigree
Lipomatosis
Blood Group Antigens
Systemic Lupus Erythematosus
Genes
Enzymes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis. / Weinberg, J. B.; Hasstedt, S. J.; Skolnick, M. H.; Kimberling, W. J.; Baty, B.

In: American journal of medical genetics, Vol. 5, No. 1, 01.12.1980, p. 57-67.

Research output: Contribution to journalArticle

Weinberg, J. B. ; Hasstedt, S. J. ; Skolnick, M. H. ; Kimberling, W. J. ; Baty, B. / Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis. In: American journal of medical genetics. 1980 ; Vol. 5, No. 1. pp. 57-67.
@article{27cd561082a34af0abe7fc69b7ac2ab7,
title = "Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis",
abstract = "Elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and 58 were typed for four electrophoretic enzyme markers. Likelihood analysis of the pedigree data confirmed independent dominant inheritance for elliptocytosis and lipomatosis. BFPSTS appears dominant, but the analysis was inconclusive. No linkages were found between any disease gene and any marker gene. Two female pedigree members with BFPSTS developed systemic lupus erythematosus, a finding in agreement with the previously described association. The analysis did not lead to any conclusions about the causal relationship between the two traits.",
author = "Weinberg, {J. B.} and Hasstedt, {S. J.} and Skolnick, {M. H.} and Kimberling, {W. J.} and B. Baty",
year = "1980",
month = "12",
day = "1",
doi = "10.1002/ajmg.1320050108",
language = "English (US)",
volume = "5",
pages = "57--67",
journal = "American Journal of Medical Genetics, Part A",
issn = "1552-4825",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Analysis of a large pedigree with elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis

AU - Weinberg, J. B.

AU - Hasstedt, S. J.

AU - Skolnick, M. H.

AU - Kimberling, W. J.

AU - Baty, B.

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and 58 were typed for four electrophoretic enzyme markers. Likelihood analysis of the pedigree data confirmed independent dominant inheritance for elliptocytosis and lipomatosis. BFPSTS appears dominant, but the analysis was inconclusive. No linkages were found between any disease gene and any marker gene. Two female pedigree members with BFPSTS developed systemic lupus erythematosus, a finding in agreement with the previously described association. The analysis did not lead to any conclusions about the causal relationship between the two traits.

AB - Elliptocytosis, multiple lipomatosis, and biological false-positive serological test for syphilis (BFPSTS) were found in a single individual. One hundred eighty relatives were tested for the three diseases: 74 were typed for seven blood group antigens, and 58 were typed for four electrophoretic enzyme markers. Likelihood analysis of the pedigree data confirmed independent dominant inheritance for elliptocytosis and lipomatosis. BFPSTS appears dominant, but the analysis was inconclusive. No linkages were found between any disease gene and any marker gene. Two female pedigree members with BFPSTS developed systemic lupus erythematosus, a finding in agreement with the previously described association. The analysis did not lead to any conclusions about the causal relationship between the two traits.

UR - http://www.scopus.com/inward/record.url?scp=0018956598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018956598&partnerID=8YFLogxK

U2 - 10.1002/ajmg.1320050108

DO - 10.1002/ajmg.1320050108

M3 - Article

C2 - 7395901

AN - SCOPUS:0018956598

VL - 5

SP - 57

EP - 67

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 1552-4825

IS - 1

ER -