An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease

M. Sitki Copur, Peter Ledakis, Daniel Novinski, Kai Fu, Mark Hutchins, Scot Frankforter, Kris Mleczko, Warren G. Sanger, Wing C. Chan

Research output: Contribution to journalArticle

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Abstract

Composite lymphomas constitute the presence of two different types of non-Hodgkin lymphoma or Hodgkin and non-Hodgkin lymphoma at the same anatomic site. We report an unusual case of a 73-year-old woman who initially presented with a composite lymphoma of chronic lymphocytic leukemia (CLL) and follicular lymphoma. After 5 years of follow-up and intermittent treatment, she developed Hodgkin disease with diffuse liver involvement. Biopsy of the liver showed Reed-Sternberg cells with typical morphology and immunophenotype. While fluorescent in situ hybridization (FISH) analyses for t(14;18) were positive in the lymph node tissue with follicular lymphoma, we were unable to show the same in the liver biopsy specimen. Here, we describe the clinical, morphologic, immunophenotypic, and cytogenetic features of this unusual composite lymphoma case involving CLL and follicular lymphoma, with the subsequent development of a Hodgkin lymphoma.

Original languageEnglish (US)
Pages (from-to)1071-1076
Number of pages6
JournalLeukemia and Lymphoma
Volume45
Issue number5
DOIs
StatePublished - May 1 2004

Fingerprint

Composite Lymphoma
Follicular Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Hodgkin Disease
Non-Hodgkin's Lymphoma
Liver
Reed-Sternberg Cells
Biopsy
Fluorescence In Situ Hybridization
Cytogenetics
Lymph Nodes

Keywords

  • CLL
  • Composite lymphoma
  • Follicular
  • Hodgkin

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease. / Copur, M. Sitki; Ledakis, Peter; Novinski, Daniel; Fu, Kai; Hutchins, Mark; Frankforter, Scot; Mleczko, Kris; Sanger, Warren G.; Chan, Wing C.

In: Leukemia and Lymphoma, Vol. 45, No. 5, 01.05.2004, p. 1071-1076.

Research output: Contribution to journalArticle

Copur, MS, Ledakis, P, Novinski, D, Fu, K, Hutchins, M, Frankforter, S, Mleczko, K, Sanger, WG & Chan, WC 2004, 'An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease', Leukemia and Lymphoma, vol. 45, no. 5, pp. 1071-1076. https://doi.org/10.1080/1042819032000159870
Copur, M. Sitki ; Ledakis, Peter ; Novinski, Daniel ; Fu, Kai ; Hutchins, Mark ; Frankforter, Scot ; Mleczko, Kris ; Sanger, Warren G. ; Chan, Wing C. / An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease. In: Leukemia and Lymphoma. 2004 ; Vol. 45, No. 5. pp. 1071-1076.
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