An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease

Bartolome R. Celli, Marc Decramer, Jadwiga A. Wedzicha, Kevin C. Wilson, Alvar Agustí, Gerard J. Criner, William MacNee, Barry J. Make, Stephen I. Rennard, Robert A. Stockley, Claus Vogelmeier, Antonio Anzueto, David H. Au, Peter J. Barnes, Pierre Regis Burgel, Peter M. Calverley, Ciro Casanova, Enrico M. Clini, Christopher B. Cooper, Harvey O. CoxsonDaniel J. Dusser, Leonardo M. Fabbri, Bonnie Fahy, Gary T. Ferguson, Andrew Fisher, Monica J. Fletcher, Maurice Hayot, John R. Hurst, Paul W. Jones, Donald A. Mahler, François Maltais, David M. Mannino, Fernando J. Martinez, Marc Miravitlles, Paula M. Meek, Alberto Papi, Klaus F. Rabe, Nicolas Roche, Frank C. Sciurba, Sanjay Sethi, Nikos Siafakas, Don D. Sin, Joan B. Soriano, James K. Stoller, Donald P. Tashkin, Thierry Troosters, Geert M. Verleden, Johny Verschakelen, Jorgen Vestbo, John W. Walsh, George R. Washko, Robert A. Wise, Emiel F.M. Wouters, Richard L. ZuWallack

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Methods: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. Results: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Conclusions: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.

Original languageEnglish (US)
Pages (from-to)e4-e27
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume191
Issue number7
DOIs
StatePublished - Apr 1 2015

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Chronic Obstructive Pulmonary Disease
Research
Research Personnel
Disease Management
Thorax
Morbidity
Mortality

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

An Official American Thoracic Society/European Respiratory Society Statement : Research questions in chronic obstructive pulmonary disease. / Celli, Bartolome R.; Decramer, Marc; Wedzicha, Jadwiga A.; Wilson, Kevin C.; Agustí, Alvar; Criner, Gerard J.; MacNee, William; Make, Barry J.; Rennard, Stephen I.; Stockley, Robert A.; Vogelmeier, Claus; Anzueto, Antonio; Au, David H.; Barnes, Peter J.; Burgel, Pierre Regis; Calverley, Peter M.; Casanova, Ciro; Clini, Enrico M.; Cooper, Christopher B.; Coxson, Harvey O.; Dusser, Daniel J.; Fabbri, Leonardo M.; Fahy, Bonnie; Ferguson, Gary T.; Fisher, Andrew; Fletcher, Monica J.; Hayot, Maurice; Hurst, John R.; Jones, Paul W.; Mahler, Donald A.; Maltais, François; Mannino, David M.; Martinez, Fernando J.; Miravitlles, Marc; Meek, Paula M.; Papi, Alberto; Rabe, Klaus F.; Roche, Nicolas; Sciurba, Frank C.; Sethi, Sanjay; Siafakas, Nikos; Sin, Don D.; Soriano, Joan B.; Stoller, James K.; Tashkin, Donald P.; Troosters, Thierry; Verleden, Geert M.; Verschakelen, Johny; Vestbo, Jorgen; Walsh, John W.; Washko, George R.; Wise, Robert A.; Wouters, Emiel F.M.; ZuWallack, Richard L.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 191, No. 7, 01.04.2015, p. e4-e27.

Research output: Contribution to journalArticle

Celli, BR, Decramer, M, Wedzicha, JA, Wilson, KC, Agustí, A, Criner, GJ, MacNee, W, Make, BJ, Rennard, SI, Stockley, RA, Vogelmeier, C, Anzueto, A, Au, DH, Barnes, PJ, Burgel, PR, Calverley, PM, Casanova, C, Clini, EM, Cooper, CB, Coxson, HO, Dusser, DJ, Fabbri, LM, Fahy, B, Ferguson, GT, Fisher, A, Fletcher, MJ, Hayot, M, Hurst, JR, Jones, PW, Mahler, DA, Maltais, F, Mannino, DM, Martinez, FJ, Miravitlles, M, Meek, PM, Papi, A, Rabe, KF, Roche, N, Sciurba, FC, Sethi, S, Siafakas, N, Sin, DD, Soriano, JB, Stoller, JK, Tashkin, DP, Troosters, T, Verleden, GM, Verschakelen, J, Vestbo, J, Walsh, JW, Washko, GR, Wise, RA, Wouters, EFM & ZuWallack, RL 2015, 'An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, vol. 191, no. 7, pp. e4-e27. https://doi.org/10.1164/rccm.201501-0044ST
Celli, Bartolome R. ; Decramer, Marc ; Wedzicha, Jadwiga A. ; Wilson, Kevin C. ; Agustí, Alvar ; Criner, Gerard J. ; MacNee, William ; Make, Barry J. ; Rennard, Stephen I. ; Stockley, Robert A. ; Vogelmeier, Claus ; Anzueto, Antonio ; Au, David H. ; Barnes, Peter J. ; Burgel, Pierre Regis ; Calverley, Peter M. ; Casanova, Ciro ; Clini, Enrico M. ; Cooper, Christopher B. ; Coxson, Harvey O. ; Dusser, Daniel J. ; Fabbri, Leonardo M. ; Fahy, Bonnie ; Ferguson, Gary T. ; Fisher, Andrew ; Fletcher, Monica J. ; Hayot, Maurice ; Hurst, John R. ; Jones, Paul W. ; Mahler, Donald A. ; Maltais, François ; Mannino, David M. ; Martinez, Fernando J. ; Miravitlles, Marc ; Meek, Paula M. ; Papi, Alberto ; Rabe, Klaus F. ; Roche, Nicolas ; Sciurba, Frank C. ; Sethi, Sanjay ; Siafakas, Nikos ; Sin, Don D. ; Soriano, Joan B. ; Stoller, James K. ; Tashkin, Donald P. ; Troosters, Thierry ; Verleden, Geert M. ; Verschakelen, Johny ; Vestbo, Jorgen ; Walsh, John W. ; Washko, George R. ; Wise, Robert A. ; Wouters, Emiel F.M. ; ZuWallack, Richard L. / An Official American Thoracic Society/European Respiratory Society Statement : Research questions in chronic obstructive pulmonary disease. In: American Journal of Respiratory and Critical Care Medicine. 2015 ; Vol. 191, No. 7. pp. e4-e27.
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abstract = "Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Methods: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. Results: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Conclusions: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.",
author = "Celli, {Bartolome R.} and Marc Decramer and Wedzicha, {Jadwiga A.} and Wilson, {Kevin C.} and Alvar Agust{\'i} and Criner, {Gerard J.} and William MacNee and Make, {Barry J.} and Rennard, {Stephen I.} and Stockley, {Robert A.} and Claus Vogelmeier and Antonio Anzueto and Au, {David H.} and Barnes, {Peter J.} and Burgel, {Pierre Regis} and Calverley, {Peter M.} and Ciro Casanova and Clini, {Enrico M.} and Cooper, {Christopher B.} and Coxson, {Harvey O.} and Dusser, {Daniel J.} and Fabbri, {Leonardo M.} and Bonnie Fahy and Ferguson, {Gary T.} and Andrew Fisher and Fletcher, {Monica J.} and Maurice Hayot and Hurst, {John R.} and Jones, {Paul W.} and Mahler, {Donald A.} and Fran{\cc}ois Maltais and Mannino, {David M.} and Martinez, {Fernando J.} and Marc Miravitlles and Meek, {Paula M.} and Alberto Papi and Rabe, {Klaus F.} and Nicolas Roche and Sciurba, {Frank C.} and Sanjay Sethi and Nikos Siafakas and Sin, {Don D.} and Soriano, {Joan B.} and Stoller, {James K.} and Tashkin, {Donald P.} and Thierry Troosters and Verleden, {Geert M.} and Johny Verschakelen and Jorgen Vestbo and Walsh, {John W.} and Washko, {George R.} and Wise, {Robert A.} and Wouters, {Emiel F.M.} and ZuWallack, {Richard L.}",
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T2 - Research questions in chronic obstructive pulmonary disease

AU - Celli, Bartolome R.

AU - Decramer, Marc

AU - Wedzicha, Jadwiga A.

AU - Wilson, Kevin C.

AU - Agustí, Alvar

AU - Criner, Gerard J.

AU - MacNee, William

AU - Make, Barry J.

AU - Rennard, Stephen I.

AU - Stockley, Robert A.

AU - Vogelmeier, Claus

AU - Anzueto, Antonio

AU - Au, David H.

AU - Barnes, Peter J.

AU - Burgel, Pierre Regis

AU - Calverley, Peter M.

AU - Casanova, Ciro

AU - Clini, Enrico M.

AU - Cooper, Christopher B.

AU - Coxson, Harvey O.

AU - Dusser, Daniel J.

AU - Fabbri, Leonardo M.

AU - Fahy, Bonnie

AU - Ferguson, Gary T.

AU - Fisher, Andrew

AU - Fletcher, Monica J.

AU - Hayot, Maurice

AU - Hurst, John R.

AU - Jones, Paul W.

AU - Mahler, Donald A.

AU - Maltais, François

AU - Mannino, David M.

AU - Martinez, Fernando J.

AU - Miravitlles, Marc

AU - Meek, Paula M.

AU - Papi, Alberto

AU - Rabe, Klaus F.

AU - Roche, Nicolas

AU - Sciurba, Frank C.

AU - Sethi, Sanjay

AU - Siafakas, Nikos

AU - Sin, Don D.

AU - Soriano, Joan B.

AU - Stoller, James K.

AU - Tashkin, Donald P.

AU - Troosters, Thierry

AU - Verleden, Geert M.

AU - Verschakelen, Johny

AU - Vestbo, Jorgen

AU - Walsh, John W.

AU - Washko, George R.

AU - Wise, Robert A.

AU - Wouters, Emiel F.M.

AU - ZuWallack, Richard L.

PY - 2015/4/1

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N2 - Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Methods: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. Results: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Conclusions: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.

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