An inexpensive high-throughput nuclear magnetic resonance tube cleaning apparatus

Bo Zhang, James Hodgson, Walter Hancock, Robert Powers

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Large-scale nuclear magnetic resonance (NMR) tube cleaning is currently a bottleneck in high-throughput NMR ligand affinity screens. Expensive alternatives include discarding the NMR tubes after a single use (∼US $2-$8/tube), using commercial NMR tube cleaners (∼$15,000), and abandoning NMR tubes for flow probe technology (∼$75,000). Instead, we describe a relatively inexpensive (∼$400) and easily constructed apparatus that can clean 180 NMR tubes per hour while using a modest amount of solvent. The application of this apparatus significantly shortens the time to recycle NMR tubes while avoiding cross-contamination and tube damage.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalAnalytical Biochemistry
Volume416
Issue number2
DOIs
StatePublished - Sep 15 2011

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Cleaning
Magnetic Resonance Spectroscopy
Throughput
Nuclear magnetic resonance
Contamination
Ligands
Technology

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

An inexpensive high-throughput nuclear magnetic resonance tube cleaning apparatus. / Zhang, Bo; Hodgson, James; Hancock, Walter; Powers, Robert.

In: Analytical Biochemistry, Vol. 416, No. 2, 15.09.2011, p. 234-236.

Research output: Contribution to journalArticle

Zhang, Bo ; Hodgson, James ; Hancock, Walter ; Powers, Robert. / An inexpensive high-throughput nuclear magnetic resonance tube cleaning apparatus. In: Analytical Biochemistry. 2011 ; Vol. 416, No. 2. pp. 234-236.
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