An inexpensive high-throughput nuclear magnetic resonance tube cleaning apparatus

Bo Zhang, James Hodgson, Walter Hancock, Robert Powers

Research output: Contribution to journalArticle

1 Scopus citations


Large-scale nuclear magnetic resonance (NMR) tube cleaning is currently a bottleneck in high-throughput NMR ligand affinity screens. Expensive alternatives include discarding the NMR tubes after a single use (∼US $2-$8/tube), using commercial NMR tube cleaners (∼$15,000), and abandoning NMR tubes for flow probe technology (∼$75,000). Instead, we describe a relatively inexpensive (∼$400) and easily constructed apparatus that can clean 180 NMR tubes per hour while using a modest amount of solvent. The application of this apparatus significantly shortens the time to recycle NMR tubes while avoiding cross-contamination and tube damage.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalAnalytical Biochemistry
Issue number2
StatePublished - Sep 15 2011


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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