An improved synthesis of psammaplin A

Amy M. Godert, Norman Angelino, Anna Woloszynska-Read, Shannon R. Morey, Smitha R. James, Adam R. Karpf, Janice R. Sufrin

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The marine natural product, psammaplin A, was first isolated from the Psammaplinaplysilla sponge in 1987. Since that time, psammaplin A has shown a wide spectrum of biological activities that include enzyme inhibitory activities resulting in antibacterial and antitumor effects. An improved synthesis of psammaplin A has been developed, making the compound more easily accessible for further biological evaluations. In this context, we find that psammaplin A is an effective DNA methyltransferase inhibitor in vitro but fails to alter genomic DNA methylation levels in treated human cancer cells.

Original languageEnglish (US)
Pages (from-to)3330-3333
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number12
DOIs
StatePublished - Jun 15 2006

Fingerprint

Methyltransferases
Enzyme activity
Porifera
DNA Methylation
Bioactivity
Biological Products
Cells
psammaplin A
DNA
Enzymes
Neoplasms
In Vitro Techniques

Keywords

  • 5-Bromo-psammaplin A
  • Cancer cells
  • DNA methylation
  • DNA methyltransferase
  • DNA methyltransferase inhibitor
  • Psammaplin A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Godert, A. M., Angelino, N., Woloszynska-Read, A., Morey, S. R., James, S. R., Karpf, A. R., & Sufrin, J. R. (2006). An improved synthesis of psammaplin A. Bioorganic and Medicinal Chemistry Letters, 16(12), 3330-3333. https://doi.org/10.1016/j.bmcl.2006.03.008

An improved synthesis of psammaplin A. / Godert, Amy M.; Angelino, Norman; Woloszynska-Read, Anna; Morey, Shannon R.; James, Smitha R.; Karpf, Adam R.; Sufrin, Janice R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 12, 15.06.2006, p. 3330-3333.

Research output: Contribution to journalArticle

Godert, AM, Angelino, N, Woloszynska-Read, A, Morey, SR, James, SR, Karpf, AR & Sufrin, JR 2006, 'An improved synthesis of psammaplin A', Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 12, pp. 3330-3333. https://doi.org/10.1016/j.bmcl.2006.03.008
Godert AM, Angelino N, Woloszynska-Read A, Morey SR, James SR, Karpf AR et al. An improved synthesis of psammaplin A. Bioorganic and Medicinal Chemistry Letters. 2006 Jun 15;16(12):3330-3333. https://doi.org/10.1016/j.bmcl.2006.03.008
Godert, Amy M. ; Angelino, Norman ; Woloszynska-Read, Anna ; Morey, Shannon R. ; James, Smitha R. ; Karpf, Adam R. ; Sufrin, Janice R. / An improved synthesis of psammaplin A. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 12. pp. 3330-3333.
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